AI Article Synopsis
- A new method has been developed for making 1,2-cis-α-linked glycosides that simplifies the process by avoiding complex protecting groups used to manage diastereoselectivity.
- The use of thioglycoside acceptors allows for repeated synthesis of oligosaccharides easily.
- This method streamlines the creation of monosaccharides, making it quicker and reducing the need for intricate protecting group chemistry.
Article Abstract
A method for the highly selective synthesis of 1,2-cis-α-linked glycosides that does not require the use of the specialized protecting group patterns normally employed to control diastereoselectivity is described. Thioglycoside acceptors can be used, permitting iterative oligosaccharide synthesis. The approach eliminates the need for lengthy syntheses of monosaccharides possessing highly specialized and unconventional protecting group patterns.
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| http://dx.doi.org/10.1021/ol401095k | DOI Listing |
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