Background: Acute ST-elevation myocardial infarction (STEMI) is associated with significant arrhythmia and cardiac arrest. QT prolongation can occur in the setting of ischemia or acute STEMI as a risk factor for arrhythmia. The goal of this study was to investigate corrected QT interval (QTc), QT dispersion (QTd), and T-wave peak to end (TPE) times in this patient population and evaluate the effect of primary percutaneous coronary intervention (PCI) in STEMI patients on these indices.
Methods: This study was a clinical trial, whereby eligible patients presenting with acute STEMI who were appropriate candidates for primary PCI were enrolled. QTc, QTd, and TPE indices were calculated before and after the procedure.
Results: Eighty patients (60 male, 20 female) with a mean age of 58.8 years were evaluated. We found significant reduction in QTd after PCI (mean, 5.8 ms before PCI vs 3.6 ms after PCI; P<.001) and significant reduction in TPE after PCI (mean, 9.7 ms before PCI vs 7 ms after PCI; P<.001). QTc did not show significant changes before or after PCI (44.9 vs 43.7; P=.057).
Conclusion: Our study showed that primary PCI was effective in reducing the degree of arrhythmogenic indices such as QTd and TPE. Our findings suggest that ischemia-induced QTd and TPE are important arrhythmogenic parameters responding to successful primary PCI and may be used as markers for successful repercussion.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Reliable peak detection and feature extraction for wireless electrocardiograms.
Comput Biol Med
December 2024
Knight Foundation School of Computing and Information Sciences, Florida International University, 11200 SW 8th St CASE 352, Miami, 33199, FL, USA. Electronic address:
The electrocardiogram (ECG) is a vital device to examine the electrical activities of the heart. It is useful for diagnosing cardiovascular diseases, which often manifest themselves through alterations in the ECG signals' characteristics. These alterations are primarily observed in the signals' key components: the Q, R, S, T, and P peaks.
View Article and Find Full Text PDFEffect of Salt Substitution on Cardiac Structure and ECG Parameters in Middle-aged and Elderly Hypertensive Patients.
Rev Cardiovasc Med
November 2024
Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, Liaoning, China.
Background: Salt substitution (SS) has been found to reduce blood pressure (BP). However, the impact of SS on cardiac structure, as assessed through ultrasonic cardiogram (UCG) and electrocardiograms (ECG), remains poorly understood. This study aims to evaluate the effects of SS on cardiac structure and ECG parameters.
View Article and Find Full Text PDFFerric carboxymaltose reduces the burden of arrhythmic events in heart failure with reduced ejection fraction: the role of the non-invasive arrhythmic biomarkers.
Hellenic J Cardiol
November 2024
Third Cardiology Department, School of Medicine, Aristotle University of Thessaloniki, Hippokrateion General Hospital, Thessaloniki, Greece. Electronic address:
Objective: Treating iron deficiency (ID) with ferric carboxymaltose (FCM) in patients with heart failure with reduced ejection fraction (HFrEF) enhances morbidity, quality of life (QoL), and exercise capacity.
Methods: In the presented single-center, prospective follow-up study, symptomatic patients with HFrEF with ID and CIEDs scheduled for IV FCM were followed up for 12-months. Arrhythmic activity was evaluated from CIEDs and non-invasive markers from Holter recordings before and after FCM.
Diagnostic Value of Magnetocardiography to Detect Abnormal Myocardial Perfusion: A Pilot Study.
Rev Cardiovasc Med
October 2024
Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Article Synopsis
- - Magnetocardiography (MCG) is a new non-invasive method that detects weak magnetic fields created by the heart's electrical activity, aiming to identify issues like myocardial ischemia by comparing its results to single-photon emission computed tomography (SPECT).
- - The study involved 112 patients with chest pain who underwent both SPECT and MCG scans, and researchers used machine learning techniques (random forest, decision tree, support vector machine) to analyze data and predict impaired blood flow to the heart.
- - Five key MCG variables were found to effectively predict impaired myocardial perfusion, with the study showing high sensitivity in the machine learning models, although specificity was generally lower, highlighting MCG's potential as a valuable future tool
Expect the unexpected: fulminant myocardial cytotoxic Injury from Trabectedin.
Cardiooncology
October 2024
Memorial Sloan Kettering Cancer Center | Weill Cornell Medicine, 1275 York Ave, New York, NY, 10065, USA.
Background: Trabectedin (Tbt) is an alkylating agent prescribed for soft tissue sarcomas after treatment failure of first line agents. While cardiomyopathy can occur with Tbt treatment after anthracycline exposure, Tbt-induced fulminant myocardial cytotoxic injury in the setting of other systemic cytotoxicity associated with Tbt has not been reported.
Case Presentation: 51-year-old female with hypertension, hyperlipidemia, metastatic leiomyosarcoma with progression of disease despite several lines of chemotherapy including doxorubicin-based therapy was started on Trabectedin (Tbt) 5 days prior to presentation with symptoms of fever, myalgias, arthralgias, and palpitations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!