AI Article Synopsis
- The study examines how a mixture of 12 pharmaceuticals adsorbs onto trimethylsilylated mesoporous SBA-15, focusing on factors like pH and the compounds' properties (hydrophobicity and acidity).
- Good relationships between adsorption and pH-dependent coefficients suggest that hydrophobic interactions primarily drive the process, with neutral species of the compounds being the most significantly adsorbed.
- Different models were used to evaluate adsorption kinetics, revealing that lower capacity pharmaceuticals fit a first-order model while higher capacity ones fit a pseudo-second-order model, with various diffusion processes serving as the rate-limiting steps.
Article Abstract
The adsorption of a complex mixture of 12 selected pharmaceuticals to trimethylsilylated mesoporous SBA-15 (TMS-SBA-15) has been investigated by batch adsorption experiments. The adsorption of pharmaceuticals to TMS-SBA-15 was highly dependent on the solution pH and pharmaceutical properties (i.e., hydrophobicity (logKow) and acidity (pKa)). Good log-log linear relationships between the adsorption (Kd) and pH-dependent octanol-water coefficients (Kow(pH)) were then established among the neutral, anionic, and cationic compounds, suggesting hydrophobic interaction as a primary driving force in the adsorption. In addition, the neutral species of each compound accounted for a major contribution to the overall compound adsorption onto TMS-SBA-15. The adsorption kinetics of pharmaceuticals was evaluated by the nonlinear first-order and pseudo-second-order models. The first-order model gave a better fit for five pharmaceuticals with lower adsorption capacity, whereas the pseudo-second-order model fitted better for seven pharmaceuticals having higher adsorption capacity. In the same group of properties, pharmaceuticals having higher adsorption capacity exhibited faster adsorption rates. The rate-limiting steps for adsorption of pharmaceuticals onto TMS-SBA-15 are boundary layer diffusion and intraparticle diffusion including diffusion in mesopores and micropores. In addition, the adsorption of pharmaceuticals to TMS-SBA-15 was not influenced by the change of initial pharmaceutical concentration (10-100μgL(-1)) and the presence of natural organic matter.
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| http://dx.doi.org/10.1016/j.jhazmat.2013.04.003 | DOI Listing |
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