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Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons.
Biol Psychiatry
October 2024
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Melbourne, Victoria, Australia; St. Vincent's Institute of Medical Research, Melbourne, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia. Electronic address:
Article Synopsis
- The causes of autism spectrum disorder (ASD) are not fully understood, but over 1,000 rare genetic variations are linked to the condition, complicating the search for common biological targets for therapy.
- CAMK4, a gene encoding an enzyme critical for brain development and function, has emerged as a potential risk gene for ASD, particularly in connection to certain genetic variants related to hyperkinetic movement disorders.
- The review emphasizes that defects in the CaMK4 signaling pathway may play a significant role in ASD pathogenesis, suggesting it as a promising target for future therapeutic interventions.
Connecting Mindfulness Practice to Generative Semiotic Activity-Self-Other Referent in Umwelt and Semiosphere.
Integr Psychol Behav Sci
September 2024
Ritsumeikan University, Kyoto, Japan.
In this comment paper on von Fircks (2023a), I would like to focus on four issues and offer some reflections on them: first, what is happening in the process of a new I arising through mindfulness meditation practice? I would like to supplement the dialogue between Buber and Rogers in 1957 on the dynamism of I and Me, which is the basis of Mead's theory of self formation, in which I and Me separate, discover and meet a new self. The second, is that meditation, which at first glance appears to be an internal meditation practice and a personal activity, leads to a semiotic mediated social process. The Tao and early Buddhist ideas that form the background to the experiential process of mindfulness meditation will be reviewed, and the significance of people experiencing the interdependence of non-human nature and the environment through the practice will be discussed.
View Article and Find Full Text PDFSubstantia Nigra Pathology, Contact Sports Play, and Parkinsonism in Chronic Traumatic Encephalopathy.
JAMA Neurol
September 2024
Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts.
Article Synopsis
- Parkinsonism is often linked to chronic traumatic encephalopathy (CTE) caused by repetitive head injuries, but the exact causes of parkinsonism in CTE patients are not fully understood.
- This study examined brain donors diagnosed with CTE to determine how often parkinsonism occurs and its relationship with brain damage due to past sports-related injuries.
- Results indicated that 24.7% of CTE participants experienced parkinsonism, which was associated with older age, higher dementia rates, and more severe stages of CTE, suggesting a significant connection between the severity of CTE and parkinsonism.
Letter to the Editor: "Effect of Graded Motor Imagery Combined With Repetitive Transcranial Magnetic Stimulation on Upper Extremity Motor Function in Stroke Patients: A Randomized Controlled Trial".
Arch Phys Med Rehabil
October 2024
Department of Occupational Therapy, Qatar Rehabilitation Institute, Hamad Medical Corporation, Doha, Qatar. Electronic address:
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