In this paper, we establish the mathematical framework of a novel imaging technique, namely photo-magnetic imaging (PMI). PMI uses a laser to illuminate biological tissues and measure the induced temperature variations using magnetic resonance imaging (MRI). PMI overcomes the limitation of conventional optical imaging and allows imaging of the optical contrast at MRI spatial resolution. The image reconstruction for PMI, using a finite-element-based algorithm with an iterative approach, is presented in this paper. The quantitative accuracy of PMI is investigated for various inclusion sizes, depths and absorption values. Then, a comparison between conventional diffuse optical tomography (DOT) and PMI is carried out to illustrate the superior performance of PMI. An example is presented showing that two 2 mm diameter inclusions embedded 4.5 mm deep and located side by side in a 25 mm diameter circular geometry medium are recovered as a single 6 mm diameter object with DOT. However, these two objects are not only effectively resolved with PMI, but their true concentrations are also recovered successfully.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031318 | PMC |
| http://dx.doi.org/10.1088/0031-9155/58/11/3551 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phototactic/Photosynthetic/Magnetic-Powered Chlamydomonas Reinhardtii-Metal-Organic Frameworks Micro/Nanomotors for Intelligent Thrombolytic Management and Ischemia Alleviation.
Adv Healthc Mater
November 2024
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, New Taipei City, 235603, Taiwan.
Thrombosis presents a critical health threat globally, with high mortality and incidence rates. Clinical treatment faces challenges such as low thrombolytic agent bioavailability, thrombosis recurrence, ischemic hypoxia damage, and neural degeneration. This study developed biocompatible Chlamydomonas Reinhardtii micromotors (CHL) with photo/magnetic capabilities to address these needs.
View Article and Find Full Text PDFSelf-Guided Algorithm for Fast Image Reconstruction in Photo-Magnetic Imaging: Artificial Intelligence-Assisted Approach.
Bioengineering (Basel)
January 2024
Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, CA 92697, USA.
Previously, we introduced photomagnetic imaging (PMI) that synergistically utilizes laser light to slightly elevate the tissue temperature and magnetic resonance thermometry (MRT) to measure the induced temperature. The MRT temperature maps are then converted into absorption maps using a dedicated PMI image reconstruction algorithm. In the MRT maps, the presence of abnormalities such as tumors would create a notable high contrast due to their higher hemoglobin levels.
View Article and Find Full Text PDFGold nanoparticle-mediated photothermal therapy guidance with multi-wavelength photomagnetic imaging.
Photodiagnosis Photodyn Ther
February 2024
Department of Radiological Sciences, University of California Irvine, USA. Electronic address:
Difficulty in heating tumors with high spatial selectivity while protecting surrounding healthy tissues from thermal harm is a challenge for cancer photothermal treatment (PTT). To mitigate this problem, PTT mediated by photothermal agents (PTAs) has been established as a potential therapeutic technique to boost selectivity and reduce damage to surrounding healthy tissues. Various gold nanoparticles (AuNP) have been effectively utilized as PTAs, mainly using strategies to target cancerous tissue and increase selective thermal damage.
View Article and Find Full Text PDFPlasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics.
Adv Healthc Mater
November 2023
Graduate Institute of Biomedical Materials and Tissue Engineering, International Ph.D. Program in Biomedical Engineering Graduate Institute of Biomedical Optomechatronics, School of Biomedical Engineering, Research Center of Biomedical Device, Innovation Entrepreneurship Education Center, College of Interdisciplinary Studies, Taipei Medical University, Taipei, 11031, Taiwan.
Article Synopsis
- - Traditional thrombolytic therapies struggle to effectively dissolve blood clots due to issues like poor penetration into the clots and potential side effects, reducing their overall effectiveness.
- - A new theranostic platform has been developed that is biocompatible and can be guided magnetically, allowing for targeted delivery and activation of thrombolytic agents specifically towards blood clots.
- - In tests on mice, this innovative approach showed an approximately 80% reduction in clot residues without side effects, suggesting it could significantly improve emergency thrombolytic treatments.
Synthesis of Multifunctional Eu(III) Complex Doped FeO/Au Nanocomposite for Dual Photo-Magnetic Hyperthermia and Fluorescence Bioimaging.
Molecules
January 2023
108 Military Central Hospital, 01 Tran Hung Dao, Hai Ba Trung, Hanoi 100000, Vietnam.
In this paper, the luminescent complex Eu(3-thenoyltrifluoroacetonate) was integrated with FeO and gold (Au) nanoparticles to form a multifunctional nanocomposite, FeO/Au/Eu(TTA) (FOASET NC), for dual magnetic-photothermal therapy and biomedical imaging. Upon functionalization with amine-NH, the FOASET NC exhibits a small size of 60-70 nm and strong, sharp emission at λ = 614 nm, enhanced by surface plasmon resonance (SPR) of Au nanoparticles that provided an effective label for HT29 colorectal cancer cells by fluorescence microscopy imaging. In addition, a hyperthermia temperature (42-46 °C) was completely achieved by using these FOASET NCs in an aqueous solution with three heating modes for (i) Magnetic therapy (MT), (ii) Photothermal therapy (PT), and (iii) Dual magnetic-photothermal therapy (MPT).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!