Artificial extracellular matrices play important roles in the regulation of stem cell behavior. To generate materials for tissue engineering, active functional groups, such as amino, carboxyl, and hydroxyl, are often introduced to change the properties of the biomaterial surface. In this study, we chemically modified coverslips to create surfaces with different amino densities and investigated the adhesion, migration, and differentiation of neural stem cells (NSCs) under serum-free culture conditions. We observed that a higher amino density significantly promoted NSCs attachment, enhanced neuronal differentiation and promoted excitatory synapse formation in vitro. These results indicate that the amino density significantly affected the biological behavior of NSCs. Thus, the density and impact of functional groups in extracellular matrices should be considered in the research and development of materials for tissue engineering.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887867 | PMC |
| http://dx.doi.org/10.1007/s10059-013-0046-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Integrated analysis of metabolites and enzyme activities reveals the plasticity of central carbon metabolism in grape ( cv. Cabernet Sauvignon) berries under carbon limitation.
Hortic Res
April 2025
State Key Laboratory of Plant Diversity and Specialty Crops, Beijing Key Laboratory of Grape Science and Enology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.
High temperatures increase the sugar concentration of grape ( L.) berries, which can negatively affect the composition and quality of wine, and global climate change is expected to exacerbate this problem. Modifying the source-to-sink ratio of grapevines by selective pruning is a potential strategy to mitigate this.
View Article and Find Full Text PDFNickel-supported cellulose-based porous composite for catalytic hydrogenation of oleic acid.
Int J Biol Macromol
March 2025
Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Based on the amino-functionalized corn straw cellulose-based porous material, a structurally stable and high-performance straw-based metal catalyst (PPCS@Ni) was prepared by depositing metal particles on the surface of porous straw (PCS) using an economical and environmentally friendly polymer-assisted metal deposition (PAMD) method. Due to the excellent structural stability of the metal material and the catalytic performance of nickel, PPCS@Ni exhibited outstanding catalytic efficiency, cyclic regeneration ability, and stability in the catalytic hydrogenation of oleic acid. Furthermore, after experimental screening and optimization (8 g oleic acid, 34.
View Article and Find Full Text PDFα-Zirconium Phosphate Hybrid Intercalated by Carbon Dots with High Anticorrosion Efficiency for Waterborne Epoxy Resin Composite Coating.
ACS Appl Mater Interfaces
March 2025
College of Materials, Fujian Provincial Key Laboratory of Fire Retardant Materials, Xiamen Key Laboratory of Fire Retardant Materials, Xiamen University, Xiamen, Fujian 361005, China.
In recent years, waterborne epoxy resin (WE) has garnered attention due to its lower environmental pollution compared to solvent-based coatings. However, their poor barrier properties severely limit their practical applications. In order to enhance the corrosion resistance of water-based epoxy resin coating, a highly efficient strategy of combining the barrier effect of lamellar structured zirconium phosphate (α-ZrP) and the inhibitor effect of special carbon dots by the intercalation method was proposed in this work.
View Article and Find Full Text PDFStabilization of optically inactive α-helices of peptidic foldamers through sequence control and , + 4 stapling.
Org Biomol Chem
March 2025
Research Center for Negative Emissions Technologies, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.
We report the effect of a minimal (, + 4) staple on the dynamic interconversion between right-handed () and left-handed () forms of an optically inactive α-helical peptide composed only of helicogenic achiral amino acids, such as 1-amino-cyclohexanecarboxylic acid (Acc) and 4-aminopiperidine-4-carboxylic acid (Api) residues. The / interconversion rate of the peptide with a flexible hydrocarbon-based staple was estimated to be 0.41 s at 298 K through variable temperature H NMR measurements in 1,1,2,2-tetrachloroethane-.
View Article and Find Full Text PDFExploring the enzyme inhibitor potential and therapeutic applications of transition metal complexes of Methoxy-Schiff Base via triangular investigation.
Int J Biol Macromol
March 2025
Research Department of Chemistry, VHNSN College (Autonomous), Virudhunagar 626001, India. Electronic address:
Transition metal(II) complexes of (E)-7-methoxy-N-(4-methoxybenzylidene)benzo[d]- thiazole-2-amine Schiff base ligand have been created using benzothiazole derivative. These compounds were characterized by means of conventional spectroscopic and analytical techniques. Furthermore, computational investigations with SWISS ADMET, Density Functional Theory, and molecular docking, authorized the biological efficacy of the complexes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!