Analysis of the values of hemodynamics and the results of open biopsy of the lung in 60 patients with ventricular septal defect and high-level pulmonary hypertension, as well as the results of surgical treatment of 30 of them showed the expediency of diagnostic open biopsy of the lung in patients of the IIIb hemodynamic group, except for patients whose hemodynamic values range as follows: the ratio of general pulmonary to general peripheral resistance in more than 0.7; the ratio of pulmonary to systemic circulation is less than 1.5; the arteriovenous shunt is less than 25%, and the mean pulmonary artery pressure is above 75 mm Hg, and these hemodynamic values correspond with the morphological changes characteristic of stage IV-V after Heat-Edwards.
Download full-text PDF |
Source |
---|
Sci Rep
January 2025
Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
L-type amino acid transporter 1 (LAT1, SLC7A5), overexpressed in various cancers, mediates the uptake of essential amino acids crucial for tumor growth. It has emerged as a promising target for cancer therapy. Nanvuranlat (JPH203/KYT-0353), a LAT1 inhibitor, has shown antitumor activity in preclinical studies and efficacy in biliary tract cancer during clinical trials.
View Article and Find Full Text PDFJ Immunother Cancer
January 2025
Department of Oncology, Uppsala University Hospital, Uppsala, Sweden
Background: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.
Methods: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to patients with advanced, unresectable solid tumors having received multiple standard-of-care treatments.
Hand Surg Rehabil
January 2025
Unidade do Punho e Mão, Hospital Cuf Tejo, Lisboa, Portugal; Centre Hospitalier Régional Universitaire de Nîmes, Department of Orthopaedic Surgery, Nîmes, France; Orthopaedic Group Ormeau Pyrénées, Polyclinique de L'Ormeau - ELSAN, Tarbes, France.
Compression of the median nerve in the carpal tunnel is a frequent pathology with severe functional impact. An ultrasound-guided technique was developed to preserve structures, diminish scar fibrosis and enable fast return to full activity. Its advantages are safety and low additional cost.
View Article and Find Full Text PDFCancer Control
January 2025
Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
Introduction: Total pelvic exenteration (TPE) for clinical T4b colorectal cancer (CRC) is associated with significant morbidity. Short (0-30 days)- and intermediate (31-90 days)-term temporal analysis of complication onset is not well described, yet needed, to better counsel patients considering TPE.
Methods: A retrospective cohort study of consecutive patients with primary or recurrent clinical T4b pelvic CRC undergoing open TPE between 2014 and 2023 was conducted.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!