A series of bis-indolone-N-oxides, 1a-f, was prepared from bis(ethynyl)benzenes and o-halonitroaryls and studied for their in vitro antiplasmodial activities against Plasmodium falciparum and representative strains of bacteria and candida as well as for their cytotoxicity against a human tumor cell line (MCF7). They did not cause any haemolysis (300 μgmL(-1)). Of the synthesized bis-indolones, compound 1a had the most potent antiplasmodial activity (IC50=0.763 μmolL(-1) on the FcB1 strain) with a selectivity index (CC50 MCF7/IC50 FcB1) of 35.6. No potency against the tested microbial strains was observed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bioorg.2013.03.001 | DOI Listing |
Publication Analysis
Top Keywords
synthesis biological
4
biological evaluation
4
evaluation bis-indolone-n-oxides
4
bis-indolone-n-oxides series
4
series bis-indolone-n-oxides
4
bis-indolone-n-oxides 1a-f
4
1a-f prepared
4
prepared bisethynylbenzenes
4
bisethynylbenzenes o-halonitroaryls
4
o-halonitroaryls studied
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!