Objective: To compare the behaviour of the PSAcomplex/PSAtotal percentage (PSAc%) against the PSA free/PSA total (PSAl%) and analyse both markers for their usefulness in diagnosing prostate cancer.
Material And Methods: We measured total PSA (PSAt), free PSA (PSAl), complex PSA (PSAc), PSAl% and PSAc% levels in 158 patients. Of these, 98 (62%) were biopsied for presenting PSAt≥3 ng/dl and PSAl%<20, PSAt>10, suspicious rectal examination or suspicious ultrasound node. We performed linear regression and Passing-Bablok regression analyses. The ROC curves were calculated to study the sensitivity and specificity of PSAl% and PSAc% and were compared to each other. The prostate cancer diagnoses were analysed by PSAl% and PSAc% by applying the χ(2) test.
Results: The correlation coefficient (r) was good (0.7447, P<.0001), and the index of determination (r(2)) was 0,5. The result of the Passing-Bablok analysis was a slope of 1.658 (1.452 to 1.897) and an intersection of 2.044 (-0,936 to 5.393). The optimal cutoff for PSAl% (≤14.7854) showed a sensitivity of 89.29% [95% CI, 0,642-0,823] and a specificity of 54.29% (95% CI, 0,642-0,823). The optimal cutoff for PSAc% (>89.7796) had a sensitivity of 71.43% (95% CI, 0,616-0,802) and a specificity of 71.43% (95% CI, 0,616-0,802). There were no significant differences when comparing the areas under the curve of both markers (P=.59). The PPV of PSAl% was less than that of PSAc% (45.7% vs. 71%).
Conclusion: There was a good correlation between PSAl% and PSAc%. PSAc% has demonstrated greater specificity and efficacy than PSAl% in the diagnosis of prostate cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.acuro.2012.11.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Adaptation mechanisms of microalgal-bacterial granular sludge to outdoor light-limited conditions.
Environ Res
December 2023
Department of Water and Wastewater Engineering, School of Urban Construction, Wuhan University of Science and Technology, Wuhan, 430065, China; Hubei Provincial Engineering Research Center of Urban Regeneration, Wuhan University of Science and Technology, Wuhan, 430065, China. Electronic address:
Microalgal-bacterial granular sludge (MBGS) has attached attention for sustainable wastewater treatment, but it remains elusive whether it can adapt to outdoor light-limited conditions. This paper investigated the biological adaptation mechanisms of MBGS to outdoor light-limited diel conditions using real municipal wastewater. The results indicated that MBGS still had excellent pollutants removal performance, and that both the extracellular polymeric substances and glycogen content of MBGS increased significantly.
View Article and Find Full Text PDFFlow cytometry-based study of model marine microalgal consortia revealed an ecological advantage of siderophore utilization by the dinoflagellate .
Comput Struct Biotechnol J
December 2021
Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Vestec, Czech.
Article Synopsis
- Investigations into how phytoplankton handle iron stress are complex because iron concentrations don't always indicate how available the iron is for them to use.
- Previous studies have focused on either single species or field samples, making the results difficult to interpret. This study used a cocultivation model to assess competition between species based on different iron levels and forms, as well as nutritional conditions.
- The research found that a specific dinoflagellate can utilize iron from hydroxamate siderophores, giving it an ecological advantage, and identified a candidate protein related to this iron acquisition strategy, which is not well understood in other eukaryotic phytoplankton.
Toxic effects of heavy metal Cd and Zn on chlorophyll, carotenoid metabolism and photosynthetic function in tobacco leaves revealed by physiological and proteomics analysis.
Ecotoxicol Environ Saf
October 2020
Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Sciences, Northeast Forestry University, Harbin, Heilongjiang, China. Electronic address:
To explore the mechanisms underlying the action of the heavy metals Cd and Zn on the photosynthetic function of plant leaves, the effects of 100 μmol L Cd and 200 μmol L Zn stress (the exposure concentrations of Cd and Zn in the culture medium were 2.24 mg kg and 5.36 mg kg) on the chlorophyll and carotenoid contents as well as the photosynthetic function of tobacco leaves (Long Jiang 911) were studied.
View Article and Find Full Text PDFCorrelation between the complex PSA/total PSA ratio and the free PSA/total PSA ratio, sensitivity and specificity of both markers for the diagnosis of prostate cancer.
Actas Urol Esp
September 2013
Servicio de Urología, Hospital Universitario Puerta del Mar, Cádiz, España. Electronic address:
Objective: To compare the behaviour of the PSAcomplex/PSAtotal percentage (PSAc%) against the PSA free/PSA total (PSAl%) and analyse both markers for their usefulness in diagnosing prostate cancer.
Material And Methods: We measured total PSA (PSAt), free PSA (PSAl), complex PSA (PSAc), PSAl% and PSAc% levels in 158 patients. Of these, 98 (62%) were biopsied for presenting PSAt≥3 ng/dl and PSAl%<20, PSAt>10, suspicious rectal examination or suspicious ultrasound node.
Genetic analysis of the Photosystem I subunits from the red alga, Galdieria sulphuraria.
Biochim Biophys Acta
January 2009
Department of Chemistry and Biochemistry, Arizona State University, Tempe 85287-1604, AZ, USA.
Currently, there are very little data available regarding the photosynthetic apparatus of red algae. We have analyzed the genes for Photosystem I in the recently sequenced genome of the red alga Galdieria sulphuraria. All subunits that are conserved between plants and cyanobacteria were unambiguously identified in the Galdieria genome: PsaA, PsaB, PsaC, PsaD, PsaE, PsaF, PsaI, PsaJ, PsaK and PsaL.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!