AI Article Synopsis
- A new method is introduced for converting unactivated esters into amides using amino alcohols, driven by a base.
- The process has been optimized to improve efficiency and involves various examples showcasing its effectiveness.
- The reaction yields products ranging from 40% to 100% when isolated, indicating a successful catalytic process.
Article Abstract
A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.
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| http://dx.doi.org/10.1021/ol400987p | DOI Listing |
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