AI Article Synopsis
- Fifteen new compounds derived from epi-aleuritolic acid were created and tested for their ability to fight HIV in human cells and to inhibit nitric oxide (NO) production.
- Among these derivatives, compounds 1, 2, 3, 4, 11, and 13 displayed strong anti-HIV properties, with the most effective one being 3α-2',2'-dimethylsuccinic acyl epi-aleuritolic acid (11), which had an EC50 value of 5.80 μM.
- Additionally, compounds 1, 3, 4, and 11 were found to inhibit NO production, with compound 1 showing the strongest effect (IC50 of 3.40
Article Abstract
Fifteen epi-aleuritolic acid derivatives were synthesized and evaluated for anti-HIV activity in 293 T cells and NO production inhibition activity. Of the derivatives, 1, 2, 3, 4, 11, and 13 showed relatively potent anti-HIV activity with EC50 values ranging from 5.80 to 13.30 μM. The most potent compound, 3α-2',2'-dimethylsuccinic acyl epi-aleuritolic acid (11), displayed significant anti-HIV activity with an EC50 value of 5.80 μM. Compounds 1, 3, 4, and 11 showed NO inhibition activity, with IC50 values ranging from 3.40 to 7.10 μM and compound 1 inhibited NO production with an IC50 value of 3.40 μM.
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| http://dx.doi.org/10.1080/10286020.2013.787990 | DOI Listing |
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Anti-HIV and NO production inhibition activities of epi-aleuritolic acid derivatives.
J Asian Nat Prod Res
July 2013
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Article Synopsis
- Fifteen new compounds derived from epi-aleuritolic acid were created and tested for their ability to fight HIV in human cells and to inhibit nitric oxide (NO) production.
- Among these derivatives, compounds 1, 2, 3, 4, 11, and 13 displayed strong anti-HIV properties, with the most effective one being 3α-2',2'-dimethylsuccinic acyl epi-aleuritolic acid (11), which had an EC50 value of 5.80 μM.
- Additionally, compounds 1, 3, 4, and 11 were found to inhibit NO production, with compound 1 showing the strongest effect (IC50 of 3.40
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