AI Article Synopsis
- Marchiafava-Bignami disease (MBD) is a rare disorder linked to heavy alcohol use, leading to damage in the corpus callosum, which can be detected through advanced MRI imaging.
- Patients with MBD often face severe symptoms, a high risk of mortality, and significant cognitive issues, but there are instances of better outcomes.
- A case study describes a man with chronic alcohol abuse and malabsorption who showed only mild symptoms during neurological exams, even though brain imaging revealed extensive lesions consistent with MBD.
Article Abstract
Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelization and necrosis of the corpus callosum. Diffusion-weighted (DW) MRI may reveal the lesions in patients showing serious clinical manifestations, high mortality rate and severe cognitive sequelae, though some cases with good outcome have been reported. We describe a case of a man with a history of chronic alcohol abuse associated with malabsorption; the man presented mild clinical signs on the first neurological exam, despite the presence of DW-MRI lesions, bilaterally involving entire corpus callosum, that are compatible with MBD diagnosis.
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| http://dx.doi.org/10.3109/00207454.2013.795150 | DOI Listing |
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