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Efficacy and Safety of Fixed-Dose Combinations for Pain in Older Adults.
Drugs Aging
November 2024
The Pain Clinic, Mount Alvernia Hospital, Singapore, Singapore.
Pain is common in older adults and managing pain in this population can be challenging owing to altered pharmacokinetics, multimorbidity, polypharmacy, cognitive impairment, and physical frailty. A fixed-dose combination (FDC) analgesic contains two or more pharmaceutical ingredients in a single pill and may offer more benefits when compared with loose-dose formulations. The benefits include reduced pill burden and better adherence, a broader analgesic spectrum well-suited to multimechanistic pain conditions and more predictable pharmacokinetic and pharmacodynamic properties.
View Article and Find Full Text PDFPrediction of the response to antiangiogenic sunitinib therapy by non-invasive hybrid diffuse optics in renal cell carcinoma.
Biomed Opt Express
October 2024
ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain.
Article Synopsis
- Researchers used broadband diffuse reflectance spectroscopy (DRS) and diffuse correlation spectroscopy (DCS) to assess deep tissue blood characteristics in a mouse model of clear cell renal cancer being treated with sunitinib.
- The study involved 22 treated mice and 13 untreated controls, revealing significant reductions in total hemoglobin concentration, oxygen saturation, and blood flow index during treatment.
- Findings indicated that early changes in blood flow and hemoglobin levels were linked to tumor characteristics, suggesting DRS/DCS can help predict how tumors might respond to antiangiogenic therapies.
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- Space occupying cerebral edema is a serious complication after large ischemic strokes, particularly with middle cerebral artery (MCA) occlusion, affecting about 30% of patients and peaking 2-4 days post-injury.
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Longitudinal Microbiome Changes in Children Exposed to Proton Pump Inhibitors.
Clin Transl Gastroenterol
September 2024
Gastroenterology/Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Introduction: Proton pump inhibitor (PPI) use has been associated with an increased risk of gastrointestinal and upper respiratory infections in children. There are limited longitudinal data on the effect of PPI in children. The goal of this prospective observational study was to compare the stool and oropharyngeal microbiome of children before and after starting PPIs.
View Article and Find Full Text PDFSatisfaction with a meal kit delivery program and feasibility of a phase I trial in the intervening in food insecurity to reduce and mitigate (InFoRM) childhood obesity study.
Pediatr Obes
May 2024
Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Background: Food and nutrition security interventions have been demonstrated to optimize health, prevent and treat chronic diseases among adult populations. Despite the increasing prevalence and intersection of food insecurity and childhood obesity in the United States, there are few food and nutrition security interventions targeted to children and families.
Objectives: The primary purpose of this phase I randomized, crossover trial was to assess the safety, acceptability and satisfaction of a meal kit delivery program among children with obesity living in households with food insecurity.
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