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Association of Alzheimer's Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics.
Sports Med
January 2025
Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Identification of genetic alleles associated with both Alzheimer's disease (AD) and concussion severity/recovery could help explain the association between concussion and elevated dementia risk. However, there has been little investigation into whether AD risk genes associate with concussion severity/recovery, and the limited findings are mixed.
Objective: We used AD polygenic risk scores (PRS) and APOE genotypes to investigate any such associations in the NCAA-DoD Grand Alliance CARE Consortium (CARE) dataset.
Introduction: In the last decade, concussions and subconcussive brain trauma in football and other high impact sports have become of increasing concern. Tackling, in youth football, accounts for a high proportion of head impacts and injuries, including concussions. Thus, minimizing head impact severity during tackling may help in reducing concussion risk and subconcussive brain trauma.
View Article and Find Full Text PDFPrognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study.
BMJ Ment Health
January 2025
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
Background: Traumatic brain injury (TBI) is associated with an increased risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). We aimed to identify predictors and develop models for the prediction of depression and PTSD symptoms at 6 months post-TBI.
Methods: We analysed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study.
Head and neck injuries from personal motorised vehicles in the United States.
Inj Prev
January 2025
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Background: The use of personal electric vehicles in the United States has increased head and neck injuries. This study analyses the types, frequencies, demographics and management of these injuries across motorised vehicles.
Methods: This study uses 2020-2023 data from the National Electronic Injury Surveillance System to analyse injuries from various powered vehicles, incorporating diagnostic, event-related and demographic factors.
Association Between Social Determinants of Health and Concussion Among High School Students in the United States.
J Child Neurol
January 2025
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA.
We examined the association between social determinants of health and the likelihood of sustaining a concussion among adolescents. Participants in this cross-sectional study were 7164 high school students who completed the 2021 Adolescent Behaviors and Experiences Survey (52.7% girls; mean age = 16.
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