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The degree of cross-linking of polyacrylic acid affects the fibrogenicity in rat lungs.
Sci Rep
January 2025
Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.
Polyacrylic acid (PAA) with different concentrations of cross-linker was instilled into the trachea of rats to examine the effect of PAA crosslink density on lung disorders. Methods: F344 rats were intratracheally exposed to low and high doses of PAA with cross-linker concentrations of 0.1, 1.
View Article and Find Full Text PDFMolecular dynamics of chemotactic signalling orchestrates dental pulp stem cell fibrosis during aging.
Front Cell Dev Biol
January 2025
Department of Oral Biology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Aging often triggers dental pulp fibrosis, resulting in clinical repercussions such as increased susceptibility to dental infections, compromised tooth vitality, and reduced responsiveness to dental interventions. Despite its prevalence, the precise molecular mechanisms underlying this condition remains unclear. Leveraging single-cell transcriptome analysis from both our own and publicly available datasets, we identified Ccrl2 macrophages as particularly vulnerable during the early stages of aging.
View Article and Find Full Text PDFThe Pathogenic Role of Expanded CD8⁺CD28 Angiogenic T Cells in ANCA-Associated Vasculitis.
Biomedicines
December 2024
Department of Clinical Immunology of Xijing Hospital and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.
Angiogenic T cells (Tang) are crucial in promoting angiogenesis, with the loss of CD28 serving as a marker for highly differentiated and senescent T cells. This study aims to investigate the characteristics and potential roles of CD8CD28 Tang in patients with ANCA-associated vasculitis (AAV). A cohort of AAV patients and matched healthy controls (HCs) were analyzed.
View Article and Find Full Text PDFEnniatin B alters bovine polymorphonuclear leukocytes phagocytosis and extracellular reactive oxygen species production in vitro.
Res Vet Sci
January 2025
Department of Veterinary Medicine and Animal Sciences (DIVAS), University of Milan, Via dell'Università 6, 2600 Lodi, Italy.
Enniatins (ENNs) affect human and animal health. Different ENN analogs have been identified, but Enniatin B (ENN B) is the most detected in foods and feeds. This study investigated the effect of ENN B on bovine polymorphonuclear leukocytes (PMNs) challenged with increasing ENN B concentrations (0.
View Article and Find Full Text PDFCharacteristics of neutrophil chemotaxis in bottlenose dolphin (Tursiops truncatus).
Vet Immunol Immunopathol
January 2025
Laboratory of Preventive Veterinary Medicine and Animal Health, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa-ken 252-0880, Japan. Electronic address:
Cetaceans have adapted to aquatic life by evolving various anatomic and physiologic traits, but biological defense mechanisms specific to aquatic mammals that protect against pathogenic microorganisms in the aquatic environment have not been elucidated. In this study, we investigated the migration of polymorphonuclear leukocytes in bottlenose dolphins in response to various chemotactic factors and compared the migration response with that of terrestrial animals such as cows and humans to characterize biological defense mechanisms unique to cetaceans. Bottlenose dolphin neutrophils showed strong chemotactic activity toward zymosan-activated serum and recombinant human interleukin-8 but no chemotaxis toward N-formyl-methionyl-leucyl-phenylalanine or leukotriene B at any concentration examined.
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