In the title compound, C14H8Cl2N4O2, the pyrazine rings are orthogonal to the benzene ring, making dihedral angles of 88.42 (8) and 89.22 (8)°. The Cl atoms attached to the pyrazine rings deviate by -0.0597 (5) and 0.0009 (5) Å from the ring plane. The crystal structure features C-H⋯N hydrogen bonds.
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http://dx.doi.org/10.1107/S1600536813007824 | DOI Listing |
ChemMedChem
December 2024
Nantes Université, Cibles et médicaments des infections et de l'immunité, IICiMed, UR 1155, F-44000, Nantes, France.
Our research group previously discovered CTN1122, an imidazo[1,2-a]pyrazine compound with promising antileishmanial activity against intramacrophage amastigotes of Leishmania major and L. donovani strains. CTN1122 effectively targets Leishmania casein kinase 1 (L-CK1.
View Article and Find Full Text PDFChem Asian J
November 2024
Lab of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200438, P. R. China.
A series of donor-acceptor (D-A) terpyridine derivatives with various intramolecular charge transfer interactions have been successfully synthesized bearing phenyl, methoxyphenyl, N-butyldiphenylamine (DPA), and triphenylamine (TPA) as electron-donors and terpyridine (TPY), 2,6-di(pyrazin-2-yl)pyridine (PYDPZ), and N,N-dimethylated PYDPZ (PYDPZ-2CH) as electron acceptors. Upon the introduction of pyrazine rings instead of pyridine ones and further selective N,N'-dimethylation, the intramolecular D-A interactions are significantly enhanced, resulting in the remarkable reduced intramolecular charge transfer (ICT) transitions and quenched PL emissions in CHCl solution. However, their ICT emissions are clearly recovered upon adding Zn.
View Article and Find Full Text PDFACS Appl Mater Interfaces
October 2024
School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China.
Biosafety is crucial to the common interests of all humanity. Currently, global biosafety governance is a challenge and poses significant opportunities. With the escalating challenges posed by microorganisms, there is an urgent need to develop advanced biocidal materials.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2024
State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, 510640, China.
Developing long-chain molecules with stable helical structures is of significant importance for understanding and modulating the properties and functions of helical biological macromolecules, but challenging. In this work, an effective and facile approach to stabilize folded helical structures by strengthening through-space conjugation is proposed, using new ortho-hexaphenylene (o-HP) derivatives as models. The structure-activity relationship between the through-space conjugation and charge-transport behavior of the prepared folded helical o-HP derivatives is experimentally and theoretically investigated.
View Article and Find Full Text PDFFuture Med Chem
October 2024
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudi Arabia.
Protein kinases play a key role in cellular signaling pathways including proliferation, apoptosis, inflammation and immune regulation. Therefore, targeting kinases with small molecules has emerged as a therapeutic potential in cancers and other diseases including inflammatory and autoimmune disorders. The main chemical motifs of the available small molecule kinase inhibitors are heterocyclic, nitrogen-containing and six-membered rings including pyrazine.
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