AI Article Synopsis
- Limonin has shown potential as a powerful anti-cancer agent, particularly against human liver cancer cells (HepG2), as demonstrated through cell viability and LDH leakage assays.
- The study provided evidence of limonin inducing apoptosis in HepG2 cells, confirmed by western blot analysis focusing on key proteins like Bax and Caspases.
- Limonin was found to downregulate Wnt signaling pathway components (LRP5, LRP6, and DKK), suggesting its effectiveness warrants further research in cancer treatment.
Article Abstract
Objective: The role of limonin as potent anti carcinogenic, apoptosis and chemotherapeutic agents has been supported by limited studies.
Materials And Methods: In this study, limonin is identified as a potent anti proliferative agent against human hepatoma HepG2 cells based on the cell viability study, LDH leakage assay. Induction of apoptosis in HepG2 cells by limonin was evidenced by western blot analysis of Bax, Cyclin D1, Caspase 3 and Caspase9.
Results: Since Wnt signalling is involved in the initiation and sustaining of hepatocellular carcinoma we studied differential expression of LRP5, LRP6 and DKK wnt players.
Conclusion: Limonin found to down regulate these players which forms a rationale for further investigation on effect on limonin in cancer therapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633262 | PMC |
| http://dx.doi.org/10.4103/0976-9668.107276 | DOI Listing |
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