The present work provides assistance for physicians concerning decision making in clinical borderline situations in the ICU. Based on a structured checklist the two fundamental aspects of any medical decision, the medical indication and the patient's preference are queried in a systematic way. Four possible steps of withholding and/or withdrawing therapy are discussed. Finally, recommendations regarding appropriate documentation of end of life decisions are provided.
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http://dx.doi.org/10.1055/s-0033-1343753 | DOI Listing |
Int J Mol Sci
December 2024
Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture (CAS), Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, China.
Marine microalgae are a rich source of natural products, and their amino acid-based antimicrobial agents are usually obtained by enzymatic hydrolysis, which is inefficient and limits the research on antimicrobial peptides (AMPs) from microalgae. In this study, is used as a model to predict antimicrobial peptides through high-throughput methods, and 471 putative peptides are identified based on the de novo transcriptome technique. Among them, three short peptides, P1, P6, and P7 were found to have antimicrobial activity against , , , and yeast , and they showed no hemolytic activity even at higher concentrations up to 10 mg/mL.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Entomology, Pennsylvania State University, University Park, PA 16802, USA.
Broad-spectrum crop protection technologies, such as abamectin and bifenthrin, are globally relied upon to curb the existential threats from economic crop pests such as the generalist herbivore Koch (TSSM). However, the rising cost of discovering and registering new acaricides, particularly for specialty crops, along with the increasing risk of pesticide resistance development, underscores the urgent need to preserve the efficacy of currently registered acaricides. This study examined the overall genetic mechanism underlying adaptation to abamectin and bifenthrin in populations from commercial hop fields in the Pacific Northwestern region of the USA.
View Article and Find Full Text PDFGenes (Basel)
November 2024
Yunnan Institute of Fishery Sciences Research, Kunming 650111, China.
The red-wing fish (), an endangered species native to Yunnan, is endemic to Chenghai Lake. The natural population of this species has suffered a sharp decline due to the invasion of alien fish species. Fortunately, the artificial domestication and reproduction of have been successful and this species has become an economic species locally.
View Article and Find Full Text PDFUnlabelled: Social cognition spans from perceiving agents and their interactions to making inferences based on theory of mind (ToM). Despite their frequent co-occurrence in real life, the commonality and distinction between social interaction perception and ToM at behavioral and neural levels remain unclear. Here, participants ( = 231) provided moment-by-moment ratings of four text and four audio narratives on social interactions and ToM engagement.
View Article and Find Full Text PDFCell Death Dis
January 2025
Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, 60438, Frankfurt, Germany.
The transcription factor p63 is expressed in many different isoforms as a result of differential promoter use and splicing. Some of these isoforms have very specific physiological functions in the development and maintenance of epithelial tissues and surveillance of genetic integrity in oocytes. The ASPP family of proteins is involved in modulating the transcriptional activity of the p53 protein family members, including p63.
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