AI Article Synopsis
- West Nile virus (WNV) has become widespread globally and is known to cause West Nile fever and neuroinvasive diseases in humans.
- Research indicates that survivors of WNV may face long-term health issues, including chronic kidney disease, raising concerns about the virus's impact on kidney function and its excretion via urine.
- This review aims to summarize various studies on WNV's effects on kidneys in both humans and animals, including potential risks for kidney transplant recipients and the importance of detecting WNV in urine for diagnosis.
Article Abstract
West Nile virus (WNV), the causative agent of West Nile fever and West Nile neuroinvasive disease in humans, has become endemic in many countries in all continents. Concerns on long-term mobility from WNV have arisen from recent studies that reported chronic kidney disease in patients who recovered from WNV infection, supported by data from animal models that showed prolonged excretion of the virus with urine. The purpose of this review is to summarize and discuss the results of studies in the literature that investigated WNV infection of the kidney in humans and in animal models and WNV excretion with urine, the potential damage to the kidney caused by WNV infection, the risk of WNV disease in kidney transplant recipients, the significance of detecting WNV in urine and its use in the diagnosis of WNV infection, and kidney involvement by other mosquito-borne flaviviruses.
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| http://dx.doi.org/10.1586/eri.13.34 | DOI Listing |
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