Trefoil factor 1 as a marker of mucosal damage of the gastrointestinal tract in children with sepsis.

Biomarkers

Department of Anesthesia and Intensive Care, University Children's Hospital, Brno, 62500, Czech Republic.

Published: June 2013

Intestinal ischemia and reperfusion is a common pathway for many diseases in children. The objective of our study was an analysis of Trefoil factor 1 levels dynamics in patients with SIRS or septic condition during a 5-day period. Analysis of TFF1 levels dynamics revealed that TFF1 levels kept steady state during the 5-day period. TFF1 levels were similar in patients with SIRS, sepsis and severe sepsis. Significantly higher levels of TFF1 were in patients with septic shock and MODS.

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http://dx.doi.org/10.3109/1354750X.2013.783116DOI Listing

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