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Measures to Prevent and Control COVID-19 in Skilled Nursing Facilities: A Scoping Review.
JAMA Health Forum
January 2025
Department of Health Policy and Management, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Importance: Skilled nursing facilities (SNFs) experienced high mortality during the COVID-19 pandemic, leading them to adopt preventive measures to counteract viral spread. A critical appraisal of these measures is essential to support SNFs in managing future infectious disease outbreaks.
Objective: To perform a scoping review of data and evidence on the use and effectiveness of preventive measures implemented from 2020 to 2024 to prevent COVID-19 infection in SNFs in the US.
Efficacy of Erector Spinae Plane Block on Analgesic Outcomes in Patients Undergoing Metabolic Surgery: A Meta-Analysis of Randomized Controlled Trials.
Obes Surg
January 2025
School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung City, Taiwan.
This meta-analysis evaluated the analgesic efficacy of erector spinae plane block (ESPB) in metabolic surgery through analysis of ten randomized controlled trials (786 patients). ESPB demonstrated superior pain control compared to placebo from 2-12 h postoperatively, with peak effect at 6 h and sustained movement-related pain reduction through 24 h. ESPB showed comparable analgesic efficacy to other nerve blocks within 24 h postoperatively.
View Article and Find Full Text PDFSingle-cell RNA sequencing and functional analysis reveal the role of altered glycosylation levels of hepatic macrophages in liver cirrhosis.
J Gastroenterol
January 2025
School of Medicine, Anhui University of Science & Technology, Huainan, China.
Background: Liver cirrhosis represents a critical stage of chronic liver disease, characterized by progressive liver damage, cellular dysfunction, and disrupted cell-to-cell interactions. Glycosylation, an essential post-translational modification, significantly influences cellular behavior and disease progression. Its role in cirrhosis at the single-cell level remains unclear, despite its importance.
View Article and Find Full Text PDFLeukemic cells infiltrate the ovaries without damaging ovarian reserve in an acute myeloid leukemia mouse model.
Endocrinology
January 2025
Olson Center for Women's Health, Department of Obstetrics and Gynecology, College of Medicine, University of Nebraska Medical Center, Omaha, NE.
Leukemia is one of the most common cancers in prepubertal girls and adolescents, with advances improving survival rates. However, treatments like chemotherapy and radiation are highly gonadotoxic, often causing ovarian insufficiency, early menopause, infertility, and endocrine disorders. Fertility preservation for young female cancer patients, especially prepubertal girls without mature germ cells, relies heavily on ovarian tissue cryopreservation.
View Article and Find Full Text PDFFactors Influencing Liver Cirrhosis Progression in Wilson's Disease Patients: A Retrospective Cohort Study Over 5 Years.
J Gastroenterol Hepatol
January 2025
Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Objectives: Wilson's disease (WD) is a rare autosomal recessive inherited disorder characterized by dysregulated copper metabolism, amenable to treatment with chelating agents. It manifests with hepatic and neurological symptoms, often precipitating the development of liver cirrhosis as a prominent complication. This study aims to elucidate the factors, biomarker alterations, and therapeutic modalities influencing the progression of cirrhosis in WD patients.
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