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Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits. | LitMetric
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Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits.

Vanessa K Ota Arthur A Berberian Ary Gadelha Marcos L Santoro Gustavo L Ottoni Camila T Matsuzaka Jair J Mari Maria I Melaragno Diogo R Lara Marília A C Smith Sintia I Belangero Rodrigo A Bressan

Psychiatry Res

Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo (UNIFESP), Rua Botucatu 740, Edifício Leitao da Cunha, 1° Andar, CEP 04023-900 Sao Paulo, Brazil.

Published: August 2013

We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.

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 Source
http://dx.doi.org/10.1016/j.psychres.2013.03.035DOI Listing

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