AI Article Synopsis
Article Abstract
Background: Liquid nitrogen endoscopic spray cryotherapy can safely and effectively eradicate high-grade dysplasia in Barrett's esophagus (BE-HGD). Long-term data on treatment success and safety are lacking.
Objective: To assess the long-term safety and efficacy of spray cryotherapy in patients with BE-HGD.
Design: Single-center, retrospective study.
Setting: Tertiary-care referral center.
Patients: A total of 32 patients with BE-HGD of any length.
Intervention: Patients were treated with liquid nitrogen spray cryotherapy every 8 weeks until complete eradication of HGD (CE-HGD) and intestinal metaplasia (CE-IM) was found by endoscopic biopsy. Surveillance endoscopy with biopsies was performed for at least 2 years.
Main Outcome Measurements: CE-HGD, CE-IM, durability of response, disease progression, and adverse events.
Results: CE-HGD was 100% (32/32), and CE-IM was 84% (27/32) at 2-year follow-up. At last follow-up (range 24-57 months), CE-HGD was 31/32 (97%), and CE-IM was 26/32 (81%). Recurrent HGD was found in 6 (18%), with CE-HGD in 5 after repeat treatment. One patient progressed to adenocarcinoma, downgraded to HGD after repeat cryotherapy. BE segment length ≥3 cm was associated with a higher recurrence of IM (P = .004; odds ratio 22.6) but not HGD. No serious adverse events occurred. Stricture was seen in 3 patients (9%), all successfully dilated.
Limitations: Retrospective study design, small sample size.
Conclusion: In patients with BE-HGD, liquid nitrogen spray cryotherapy has an acceptable safety profile and success rate for eliminating HGD and IM and is associated with a low rate of recurrence or progression to cancer with long-term follow-up.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.gie.2013.03.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction Bronchoscopic spray cryotherapy (SCT) is a novel treatment showing promise for chronic bronchitis (CB), characterized by excessive mucus secretion and productive cough. A large animal model for preclinical research of SCT is lacking, and its treatment's efficacy and mechanisms for CB are not well understood. Methods Eight Labradors were exposed to 200 ppm SO2 for 6 months to develop a CB model.
View Article and Find Full Text PDFEfficacy of local anesthesia with cryotherapy on teeth with molar incisal hypomineralization: a randomized control trial.
J Dent Anesth Pain Med
December 2024
Department of Pediatric and Preventive Dentistry, Kannur Dental College, Kannur, Kerala, India.
Background: Tooth hypersensitivity presents a significant clinical challenge in managing molar-incisal hypomineralization (MIH), potentially compromising the effectiveness of restorative treatments. Cryotherapy has emerged as a promising approach to reduce pain and inflammation. This study aimed to evaluate and compare the effects of cryotherapy as an adjuvant to nerve blocks in reducing operative pain and sensitivity in patients.
View Article and Find Full Text PDFPreliminary clinical evaluation of the treatment efficacy of a temperature-adjustable cryotherapy device for chronic, recurrent blepharitis in dogs.
Vet Ophthalmol
November 2024
Department of Veterinary Ophthalmology, College of Veterinary Medicine, Konkuk University, Seoul, Korea.
Objective: To preliminarily evaluate the treatment efficacy of a temperature-adjustable cryotherapy device for chronic, recurrent blepharitis in dogs.
Animals Studied: Five dogs (eight eyes) of different breeds with blepharitis, which was unresponsive to systemic steroids.
Procedures: The dogs were subjected to ophthalmic examination, including Schirmer tear test-1 (STT-1), tear film break-up time (TFBUT) test, and slit-lamp biomicroscope examination.
The safety and efficacy of spray cryotherapy after endoscopic sinus surgery in chronic rhinosinusitis: A systematic review of randomized controlled trials.
F1000Res
October 2024
Department of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.
Background: Chronic rhinosinusitis (CRS) is a condition that affects 5-12% of the general population. Endoscopic sinus surgery (ESS) is the preferred treatment because of its few adverse effects and highest success rates. The most common post-operative consequences include synechia, nasal blockage, and disease recurrence.
View Article and Find Full Text PDFInterventional pulmonology for chronic inflammatory airway diseases.
Chin Med J Pulm Crit Care Med
September 2024
Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg 69126, Germany.
Article Synopsis
- - Chronic inflammatory airway diseases like chronic bronchitis, COPD, emphysema, and asthma are significant healthcare issues that can be addressed with interventional treatments alongside standard medical therapy.
- - These minimally invasive procedures, such as bronchial thermoplasty and lung volume reduction techniques, directly target the airways to relieve symptoms and improve lung function by reducing hyperinflation and mucus production.
- - The review provides insights into various interventional methods based on specific disease types, helping pulmonologists choose the best treatment options for their patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!