The 1,4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel modulating agents and have experienced widespread use in the treatment of cardiovascular disease which include antihypertensive, antianginal, vasodilator and cardiac depressants activities. It also shows antibacterial, anticancer, antileishmanial, anticoagulant, anticonvulsant, antitubercular, antioxidant, antiulcer, CFTR, antimalarials, neuroprotection properties, HIV-1 protease inhibitors, antifertility activities and many more. There are many marketed drugs which contain 1,4-dihydropyridines ring as basic scaffold. In this review, attempts have been made to disclose various therapeutic applications of 1,4-dihydropyridine derivatives which have been reported during the period of 2001-2011.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention.
Eur J Med Res
December 2024
Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui, China.
Alarmins are a class of molecules released when affected cells damaged or undergo apoptosis. They contain various chemotactic and immunomodulatory proteins or peptides. These molecules regulate the immune response by interacting with pattern recognition receptors (PRRs) and play important roles in inflammatory response, tissue repair, infection defense, and cancer treatment.
View Article and Find Full Text PDFCircular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology/diseases.
Eur J Med Res
December 2024
School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Infertility is a prevalent problem among 10% of people within their reproductive years. Sometimes, even advanced treatment options like assisted reproduction technology have the potential to result in failed implantation. Because of the expected changes in gene expression during both in vitro and in vivo fertilization processes, these methods of assisting fertility have also been associated with undesirable pregnancy outcomes related to infertility.
View Article and Find Full Text PDFCorrection: Impact of fish oil supplementation on plasma levels of highly unsaturated fatty acid-containing lipid classes and molecular species in American football athletes.
Nutr Metab (Lond)
December 2024
School of Nutritional Sciences and Wellness, Bioscience Research Laboratory (BSRL), University of Arizona, Room 370, 1230 N Cherry Avenue, Tucson, AZ, 85719, USA.
Dentoalveolar characteristics in subjects with different anteroposterior relationships: a retrospective cross-sectional Cone-Beam Computed Tomography study.
BMC Oral Health
December 2024
College of Dental Medicine, QU Health, Qatar University, P.O. Box: 2713, Doha, Qatar.
Background: The collum angle, tooth dimensions, root length, and alveolar bone thickness have a significant impact on orthodontic diagnosis and treatment planning. The boundaries of orthodontic tooth movement are determined by alveolar bone thickness and dimensions while the collum angle determines the appropriate positioning of the root relative to the cortical plate. This study aimed to compare the collum angle, crown dimensions, root length, and alveolar bone thickness of the upper and lower incisors, canines, and premolars in subjects with varying anteroposterior relationships.
View Article and Find Full Text PDFSelf -reported bruxism in patients undergoing Orthodontic treatment - a cross-sectional study.
BMC Oral Health
December 2024
Department of Surgery, Program Director Orthodontics Residency Program, Section of Dentistry, The Aga Khan University Hospital, Stadium Road, P.O Box 3500, Karachi, 74800, Pakistan.
Background: Orthodontic treatment involves manipulation of tooth position that can temporarily lead to occlusal interferences capable of inducing bruxism. The objectives of this study were to determine the self-reported incidence of bruxism and its association with factors such as facial type, divergence, skeletal and dental malocclusions in orthodontic patients.
Materials And Methods: 80 patients who underwent a minimum of six months of orthodontic treatment were surveyed using a validated self-reported bruxism questionnaire for the presence or absence of bruxism.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!