Introduction: Albumin and α1-acid glycoprotein (AGP) are two of the most abundant proteins found in plasma. Their effect on the pharmacokinetic profile of exogenous compounds has major implications to clinical practice. Recent exploration into their possible role as diagnostic markers underlines their significance, and provides highlights their potential in medicinal applications.
Areas Covered: This review summarizes the current understanding behind albumin and AGP. Specifically, the review focuses on their structure, physiological function, and their potential use in diagnostics as biomarkers. The article lists and describes the most common methods, with a specific focus on their use in drug design and clinical practice.
Expert Opinion: Human serum albumin and AGP play a significant role in clinical practice. Research on human serum albumin and AGP, as potential diagnostic biomarkers, has been so far successful, with the development of novel diagnostic methods for detecting ischemia-modified albumin in cardiac ischemia patients. While research into this particular aspect is still in its infancy, future research should make things somewhat clearer and provide a better insight into the true potential of plasma proteins as a whole.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1517/17425255.2013.790364 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In vitro spectroscopic studies of 9-amino-5-alkyl-12(H)-quino[3,4-b][1,4]benzothiazine chloride with main carrier plasma proteins.
Chem Biol Interact
January 2025
Department of Physical Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055, Katowice, Poland. Electronic address:
Current methods of cancer treatment, particularly chemotherapy, are associated with harmful side effects. For this reason, it is significant to study new substances with anticancer potential with the highest possible efficacy and the lowest possible side effects. The aim of the study was the spectroscopic analysis of the interaction between 9-amino-5-alkyl-12(H)-quino[3,4-b][1,4]benzothiazine chloride (Salt3) and main carrier proteins, such as human serum albumin (HSA), α1 acid glycoprotein (AGP), human γ globulin (HGG) and controlled normal serum (CNS).
View Article and Find Full Text PDFCurrent or recent malaria infection is associated with elevated inflammation-adjusted ferritin concentrations in pre-school children: a secondary analysis of the BRINDA database.
Br J Nutr
October 2024
Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, LondonWC1E 7HT, UK.
Article Synopsis
- Inflammation and infections, like malaria, can alter micronutrient biomarker levels, impacting nutritional status assessments, particularly the concentrations of ferritin, which indicates iron deficiency.
- A study pooling data from eight surveys of children aged 6-59 months across several African countries revealed that current or recent malaria infection was linked to a 44% increase in inflammation-adjusted ferritin levels.
- The research also indicated that factors like age and malaria prevalence in the area influenced the relationship between malaria infection and ferritin levels, suggesting further investigation is needed to understand these dynamics.
TTR associated leptomeningeal amyloidosis in a Sri Lankan patient.
J Neurol Sci
November 2024
National Hospital for Neurology & Neurosurgery, Queen Square, London, UK; UCLH NIHR Biomedical Research Centre, London, UK.
Objectives: This case report aims to contribute to the expanding genotypic-phenotypic spectrum of TTR associated leptomeningeal amyloidosis.
Methods: Neuroimaging and targeted TTR Sanger sequencing were performed on a 52-year-old female presenting with cognitive and motor symptoms.
Results: The proband, a Sri Lankan woman, presented with a gradually progressive cognitive decline, followed by a rapid deterioration in motor function and level of consciousness.
Enantioselective Binding of Proton Pump Inhibitors to Alpha1-Acid Glycoprotein and Human Serum Albumin-A Chromatographic, Spectroscopic, and In Silico Study.
Int J Mol Sci
October 2024
Department of Pharmaceutical Chemistry, Semmelweis University, Hogyes E. 9, 1092 Budapest, Hungary.
The enantioselective binding of three proton pump inhibitors (PPIs)-omeprazole, rabeprazole, and lansoprazole-to two key plasma proteins, α1-acid glycoprotein (AGP) and human serum albumin (HSA), was characterized. The interactions between PPI enantiomers and proteins were investigated using a multifaceted analytical approach, including high-performance liquid chromatography (HPLC), fluorescence and UV spectroscopy, as well as in silico molecular docking. HPLC analysis demonstrated that all three PPIs exhibited enantioseparation on an AGP-based chiral stationary phase, suggesting stereoselective binding to AGP, while only lansoprazole showed enantioselective binding on the HSA-based column.
View Article and Find Full Text PDFAn overview of interpretability of two models of unbound fraction that are used in combination with the well-stirred model for predicting hepatic clearance of drugs.
J Pharm Sci
November 2024
Consultant Patrick Poulin Inc., Québec City, Québec, Canada; School of Public Health, Université de Montréal, Montréal, Québec, Canada. Electronic address:
Hypothetical and experimental models of unbound fraction have been proposed to facilitate predicting the hepatic clearance (CL) of drugs from values of intrinsic clearance for the unbound drug (CL) and the well-stirred model (WSM). The hypothetical model (fu) is adjusting the unbound fractions determined in plasma in vitro to estimate the maximum unbound fractions at the hepatocytes if each drug-protein complex in plasma becomes fully dissociated at the membrane by any albumin (ALB)-facilitated hepatic uptake mechanism. The model of fu is also adjusting the unbound fraction for a pH gradient effect across the membrane.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!