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The Effect of the Second Forward View on the Detection Rate of Sessile Serrated Lesions in the Proximal Colon: A Single-Center Prospective Randomized Controlled Study.
Clin Transl Gastroenterol
December 2024
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objectives: The detection rate of proximal sessile serrated lesion (PSSLDR) is linked to the incidence and mortality of colorectal cancer. However, research on second forward view (SFV) examinations for PSSLDR remains limited. This first randomized controlled trial assessed the impact of the proximal SFV on the PSSLDR.
View Article and Find Full Text PDFColorectal Neoplasia Detection Rates in Lynch Syndrome.
Cancers (Basel)
November 2024
Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Background: The expected and optimal adenoma detection rate (ADR) is not well characterized in Lynch syndrome (LS). The aim of this study is to determine the ADR, the overall colorectal neoplasia detection rate (CNDR), proximal serrated detection rate (PSDR), and CRC detection rate (CRCDR) in an LS cohort.
Methods: A retrospective study was performed of individuals with LS who were evaluated at a single tertiary care center from May 2001 to September 2023 ( = 542).
Colonoscopy Remains an Important Option for Primary Screening for Colorectal Cancer.
Dig Dis Sci
December 2024
Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Article Synopsis
- - Colonoscopy is the most commonly used screening test for colorectal cancer in the U.S., with high sensitivity for detecting precancerous lesions, allowing screenings every 10 years, and possibly every 15 years for those with normal results.
- - There is substantial evidence showing colonoscopy reduces colorectal cancer incidence and mortality, supported by various studies, including comparisons with other screening methods like flexible sigmoidoscopy.
- - Advances in colonoscopy techniques, such as improved mucosal exposure methods and non-device strategies, have enhanced detection rates of precancerous lesions, along with safer resection techniques for small lesions, increasing the effectiveness of this screening option.
Endoscopic characteristics to differentiate SSLs and microvesicular hyperplastic polyps from goblet cell-rich hyperplastic polyps.
Endosc Int Open
November 2024
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Among colorectal serrated polyps (SPs), sessile serrated lesions (SSLs) and hyperplastic polyps (HPs) have a similar endoscopic appearance. However, the endoscopic distinctions between those two categories, microvesicular HPs (MVHPs) and goblet cell-rich HPs (GCHPs), are not well understood. Therefore, we compared the endoscopic features of SSLs, MVHPs, and GCHPs.
View Article and Find Full Text PDFGermline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome.
Int J Mol Sci
November 2024
Molecular Pathobiology Research Unit (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E. (IPOLFG, EPE), Rua Professor Lima Basto, 1099-023 Lisbon, Portugal.
Serrated polyposis syndrome (SPS) is characterized by the development of multiple colorectal serrated polyps and increased predisposition to colorectal cancer (CRC). However, the molecular basis of SPS, especially in cases presenting family history of SPS and/or polyps and/or CRC in first-degree relatives (SPS-FHP/CRC), is still poorly understood. In a previous study, we proposed the existence of two molecular entities amongst SPS-FHP/CRC families, proximal/whole-colon and distal SPS-FHP/CRC, according to the preferential location of lesions and somatic events involved in tumor initiation.
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