AI Article Synopsis
- New γ-amino acid building blocks called 4-Amino(methyl)-1,3-thiazole-5-carboxylic acids (ATCs) were synthesized.
- The structures of different ATC oligomers were studied using CD and NMR spectroscopy in solution, and X-ray crystallography in the solid state.
- ATC sequences formed a stable 9-helix structure in various environments, including organic solvents and water.
Article Abstract
9-Helix: 4-Amino(methyl)-1,3-thiazole-5-carboxylic acids (ATCs) were synthesized as new γ-amino acid building blocks. The structures of various ATC oligomers were analyzed in solution by CD and NMR spectroscopy and in the solid state by X-ray crystallography. The ATC sequences adopted a well-defined 9-helix structure in the solid state and in aprotic and protic organic solvents as well as in aqueous solution.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201302106 | DOI Listing |
Publication Analysis
Top Keywords
solid state
8
helical oligomers
4
oligomers thiazole-based
4
thiazole-based γ-amino
4
γ-amino acids
4
acids synthesis
4
synthesis structural
4
structural studies
4
studies 9-helix
4
9-helix 4-aminomethyl-13-thiazole-5-carboxylic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!