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Imaging Clusters of Pediatric Low-Grade Glioma are Associated with Distinct Molecular Characteristics.
AJNR Am J Neuroradiol
February 2025
From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Background And Purpose: Cancers show heterogeneity at various levels, from genome to radiological imaging. This study aimed to explore the interplay between genomic, transcriptomic, and radiophenotypic data in pediatric low-grade glioma (pLGG), the most common group of brain tumors in children.
Materials And Methods: We analyzed data from 201 pLGG patients in the Children's Brain Tumor Network (CBTN), using principal component analysis and K-Means clustering on 881 radiomic features, along with clinical variables (age, sex, tumor location), to identify imaging clusters and examine their association with 2021 WHO pLGG classifications.
Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma.
Nat Commun
January 2025
Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Article Synopsis
- Pediatric low-grade gliomas (pLGGs) show varying treatment responses and poor outcomes when complete tumor removal isn't possible, making early treatment prediction important.
- A radiogenomic analysis combining MRI and RNA sequencing reveals three immune clusters in pLGGs, with one cluster having higher immune activity but worse prognosis, suggesting they might benefit from immunotherapy.
- A developed radiomic signature accurately predicts these immune profiles and progression-free survival, identifying high-risk patients for potential targeted therapies.
Caught between pity, explicit bias, and discrimination: a qualitative study on the impact of stigma on the quality of life of persons living with sickle cell disease in three African countries.
Qual Life Res
February 2024
Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Purpose: Sickle cell disease (SCD) is an inherited blood disorder characterized by unpredictable episodes of acute pain and numerous health complications. Individuals with SCD often face stigma from the public, including perceptions that they are lazy or weak tending to exaggerate their pain crisis, which can profoundly impact their quality of life (QoL).
Methods: In a qualitative phenomenological study conducted in Cameroon, Ghana, and Tanzania, we explored stakeholders' perceptions of SCD-related stigma using three analytical frameworks: Bronfenbrenner's Ecological Systems Theory; The Health Stigma and Discriminatory Framework; and A Public Health Framework for Reducing Stigma.
A Novel Technique and Outcomes for Transcaval Endoleak Embolization.
Ann Vasc Surg
July 2023
Department of Vascular Surgery, Sydell and Arnold Miller Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH. Electronic address:
Background: Strategies for embolization of type 2 endoleaks include translumbar, transgraft, transarterial, and transcaval approaches. The transcaval approach is limited by an inconsistent ability to access the aortic sac and the risk of puncturing and damaging the endograft or adjacent structures. We describe a novel technique for caval to aortic aneurysm sac access and report early outcomes.
View Article and Find Full Text PDFSpontaneous epidural hematoma: A case report of rare crisis of sickle cell disease.
J Family Med Prim Care
November 2021
Department of Internal Medicine, Security Forces Hospital, Riyadh, Saudi Arabia.
Introduction: Sickle cell disease (SCD) is defined as an autosomal recessive disorder characterized by the production of abnormal hemoglobin S and is correlated with high morbidity and mortality. The clinical consequences of SCD include pain crisis, acute chest syndrome, and strokes. Spontaneous epidural hematoma is a rare manifestation in sicklers with few cases reported in the literature.
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