AI Article Synopsis
- This review compares ribosome degradation in bacteria (like Escherichia coli) and eukaryotes (like Saccharomyces cerevisiae)
- While the molecular processes differ, the reasons behind ribosome degradation are strikingly similar in both organisms
- Ribosomes can be degraded during assembly due to quality control mechanisms, and even healthy ribosomes may be broken down in response to stress conditions
Article Abstract
This review takes a comparative look at the various scenarios where ribosomes are degraded in bacteria and eukaryotes with emphasis on studies involving Escherichia coli and Saccharomyces cerevisiae. While the molecular mechanisms of degradation in bacteria and yeast appear somewhat different, we argue that the underlying causes of ribosome degradation are remarkably similar. In both model organisms during ribosomal assembly, partially formed pre-ribosomal particles can be degraded by at least two different sequentially-acting quality control pathways and fully assembled but functionally faulty ribosomes can be degraded in a separate quality control pathway. In addition, ribosomes that are both structurally- and functionally-sound can be degraded as an adaptive measure to stress.
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