AI Article Synopsis
- Recent advances in non-invasive imaging techniques allow scientists to visualize molecular events in live cells, enhancing our understanding of cellular processes.
- Using infrared optical tweezers, researchers successfully manipulated red blood cells within the capillaries of living mice to clear a blocked microvessel without contact.
- This research expands the use of optical tweezers, providing new insights into live cell dynamics in an in vivo environment.
Article Abstract
The recent development of non-invasive imaging techniques has enabled the visualization of molecular events underlying cellular processes in live cells. Although microscopic objects can be readily manipulated at the cellular level, additional physiological insight is likely to be gained by manipulation of cells in vivo, which has not been achieved so far. Here we use infrared optical tweezers to trap and manipulate red blood cells within subdermal capillaries in living mice. We realize a non-contact micro-operation that results in the clearing of a blocked microvessel. Furthermore, we estimate the optical trap stiffness in the capillary. Our work expands the application of optical tweezers to the study of live cell dynamics in animals.
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| http://dx.doi.org/10.1038/ncomms2786 | DOI Listing |
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