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Tolerability and first hints for potential efficacy of motor-cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint.
Neuroprotection
September 2024
Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, City Campus, Göttingen, Germany.
Article Synopsis
- Hypoxia is increasingly recognized as a key factor that helps brain cells adapt to low oxygen levels and reduced metabolism, leading to what the authors call "functional hypoxia."
- The study investigates the effects of combined mild inspiratory and functional hypoxia during motor-cognitive training in a group of 20 participants, including healthy individuals and those with depression or autism spectrum disorder.
- Initial findings suggest that this training under low oxygen conditions is well-tolerated and may improve well-being, cognitive performance, physical fitness, and affect immune cell responses, warranting further research with a controlled trial to better assess the benefits.
Erythroferrone in focus: emerging perspectives in iron metabolism and hematopathologies.
Blood Sci
October 2024
Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Article Synopsis
- Erythroferrone (ERFE) is crucial in iron metabolism and influences several hematologic disorders, highlighting its importance in conditions like β-thalassemia and myelodysplastic syndromes.
- Dysregulation of ERFE contributes to anemia and iron overload, making it a promising therapeutic target for various iron-related diseases.
- Ongoing research into ERFE's role in chronic kidney disease and other conditions suggests that modulating its activity could lead to new treatments, emphasizing its potential in improving patient outcomes in hematology.
Effect of Step Load Based on Time under Tension in Hypoxia on the ACL Pre-Operative Rehabilitation and Hormone Levels: A Case Study.
J Clin Med
May 2024
Department of Sports Training, Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland.
The aim of the study was to determine the effect of step load in hypoxia on the effectiveness of preoperative rehabilitation (PR) and hormone levels based on a case study. : We assessed the impact of variables such as rate of movement and time under tension (TUT) in normobaric hypoxia on the levels of growth hormone (GH), insulin-like growth factor 1 (IGF-1), and erythropoietin (EPO). Additionally, the impact of step load on the hypertrophy and strength of knee extensors and flexors was assessed.
View Article and Find Full Text PDFEphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis.
Arthritis Rheumatol
August 2024
University of Utah, Salt Lake City.
Objective: Erythropoietin-producing hepatocellular (Eph)/Ephrin cell-cell signaling is emerging as a key player in tissue fibrogenesis. The aim of this study was to test the hypothesis that the receptor tyrosine kinase EphB2 mediates dermal fibrosis in systemic sclerosis (SSc).
Methods: We assessed normal and SSc human skin biopsies for EphB2 expression.
EPH/Ephrin Signaling in Normal Hematopoiesis and Hematologic Malignancies: Deciphering Their Intricate Role and Unraveling Possible New Therapeutic Targets.
Cancers (Basel)
August 2023
First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Erythropoietin-producing hepatocellular carcinoma receptors (EPHs) represent the largest family of receptor tyrosine kinases (RTKs). EPH interaction with ephrins, their membrane-bound ligands, holds a pivotal role in embryonic development, while, though less active, it is also implicated in various physiological functions during adult life. In normal hematopoiesis, different patterns of EPH/ephrin expression have been correlated with hematopoietic stem cell (HSC) maintenance and lineage-committed hematopoietic progenitor cell (HPC) differentiation, as well as with the functional properties of their mature offspring.
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