This article deals with prospective and retrospective ecological risk assessment (ERA) procedures for pesticides in surface waters as carried out under European legislation (Regulation 1107/2009/EC; Directive 2009/128/EC; Directive 2000/60/EC). Priorities to improve the aquatic risk assessment and management of pesticides are discussed on basis of the following 5 theses: 1) the management of the environmental risks of pesticides in surface water requires an appropriate implementation of feedback mechanisms between prospective and retrospective ERA, 2) an appropriate ERA cannot be carried out without well-defined specific protection goals, described in terms of focal vulnerable populations and related exposure assessment goals, 3) the interaction between the assessment of exposure and eco(toxico)logical effects in ERA is at a lower level of sophistication than either assessment of exposure or assessment of effects in the field, 4) there is insufficient experimental proof that, in prospective ERA, the chronic effect assessment procedures accurately predict long-term population- and community-level impacts, and 5) multiple stress by pesticides in aquatic ecosystems cannot be ignored in ERA, but in individual water bodies, toxicity usually is dominated by a limited number of substances.
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http://dx.doi.org/10.1002/ieam.1429 | DOI Listing |
Emergencias
December 2024
Servicio de Análisis Clínicos, Hospital Universitario Santa Lucía, Cartagena, Murcia, España.
Objective: To analyze the usefulness of mean mid-regional pro-adrenomedullin (MR-proADM) level to stratify risk in emergency department patients with solid tumors attended for febrile neutropenia after chemotherapy. To compare risk prediction with MR-proADM to that of conventional biomarkers and scores on the Multinational Association for Supportive Care in Cancer (MASCC) score.
Methods: Prospective observational cohort study enrolling patients with solid tumors who developed febrile neutropenia after chemotherapy.
Heliyon
January 2025
Faculty of Medicine and Medical Sciences, University of Balamand, Kalhat, Lebanon.
Background: Transvenous pacemakers (TVP) and leadless pacemakers (LP) are two reliable permanent modalities for the treatment of heart rhythm disorders. Several observational studies explored the safety and efficacy of the two devices. The aim of this meta-analysis study is to present a comparative analysis of the safety of leadless versus transvenous pacemakers.
View Article and Find Full Text PDFHeliyon
January 2025
Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
Neurosignaling is increasingly recognized as a critical factor in cancer progression, where neuronal innervation of primary tumors contributes to the disease's advancement. This study focuses on segmenting individual axons within the prostate tumor microenvironment, which have been challenging to detect and analyze due to their irregular morphologies. We present a novel deep learning-based approach for the automated segmentation of axons, AxonFinder, leveraging a U-Net model with a ResNet-101 encoder, based on a multiplexed imaging approach.
View Article and Find Full Text PDFGeotech Geol Eng (Dordr)
January 2025
School of Mechanical, Aerospace and Civil Engineering, The University of Sheffield, Sheffield, UK.
Earthquake induced soil liquefaction poses a significant threat to buildings and infrastructure, as evidenced by numerous catastrophic seismic events. Existing approaches of regional liquefaction hazard assessment predominantly rely on deterministic analysis methods. This paper presents a novel Probabilistic Liquefaction Hazard Analysis (PLHA) framework based on Monte-Carlo (MC) simulations to mitigate future seismic risks associated with liquefaction.
View Article and Find Full Text PDFJ Taibah Univ Med Sci
December 2024
Department of Health Administration, College of Business Administration, King Saud University, Riyadh, KSA.
Objectives: Falls and fall-related injuries among older adults are a growing public health concern. Although multiple factors and co-morbidities are associated with falls, balance and gait disorders are among the most common causes. Physical therapists have expertise in fall-risk assessment and management.
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