Knee
Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada; Centre for Hip Health and Mobility (CHHM), Robert H.N. Ho Research Centre, Vancouver, BC, Canada.
Published: March 2014
Background: Accurate comparison of outcomes regarding various surgical options in knee arthroplasty can benefit from an improved method for joint line analysis that takes into account the preoperative joint space.
Methods: This article describes a new preoperative-based registration method that measures changes in the joint line by overlaying the 3D models of the bones with implants using preoperative CT along with preoperative and postoperative biplanar radiography. The method was tested on six cadaveric specimens for measuring alteration to the medial and lateral joint lines in extension and flexion.
Results: The joint line shift, when measured using the new method, was in the range of -0.2 to 1.3 mm on average (SD=1.3 to 3.8 mm, for medial and lateral, in flexion and extension positions). This was significantly different (p≤0.01) from the results of a previous postoperative-based registration method which did not account for the cartilage thickness in calculating alterations of the joint line (mean=3.9 to 6.8mm, SD=1.2 to 4.3 mm).
Conclusion: These results further highlight the importance of considering the preoperative joint space in analyzing the joint line, and demonstrate the utility of the newly introduced method for accurate assessment of changes in the joint line after arthroplasty.
Clinical Relevance: The introduced method provides accurate means for investigating joint line alterations in relation to different surgical techniques and the subsequent biomechanical effects after knee arthroplasty.
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http://dx.doi.org/10.1016/j.knee.2013.03.011 | DOI Listing |
Knee
January 2025
Department of Orthopaedics, Juntendo University, Faculty of Medicine, Bunkyo-ku, Tokyo, Japan.
Purpose: The purpose of this study was to compare the distribution of the coronal plane alignment of the knee (CPAK) phenotype between the healthy population and the arthritic population in Japan.
Methods: The retrospective cross-sectional study included 1049 knees. There were 256 healthy individuals with a total of 512 knees and 310 individuals with a total of 537 arthritic knees who underwent around-knee osteotomy between June 2010 and January 2024.
Knee
January 2025
Department of Radiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Background: Long-leg alignment and joint line obliquity have traditionally been assessed using two-dimensional (2D) radiography, but the accuracy of this measurement has remained unclear. This study aimed to evaluate the accuracy of 2D measurements of lateral distal femoral angle (LDFA) and medial proximal tibial angle (MPTA) using upright three-dimensional (3D) computed tomography (CT).
Methods: This study involved 66 knees from 38 patients (34 women, four men) with knee osteoarthritis (OA), categorized by Kellgren-Lawrence (KL) grade.
Knee
January 2025
IULS-University Institute for Locomotion and Sports, Pasteur 2 Hospital, University Côte d'Azur, Nice, France; ICARE Team, Côte d'Azur University, Inserm, CNRS, Valrose Institute of Biology, Nice, France. Electronic address:
Background: Several studies have demonstrated the interest in patient-specific custom cutting guides in total knee arthroplasty (TKA), but clinical improvement remains debated. The purpose of this study was to evaluate the functional outcomes (Forgotten Joint Score, FJS) of patients undergoing individualized TKA compared with those receiving off-the-shelf (OTS) implants, both using patient-specific cutting guides with personalized alignment over a minimum follow up period of 12 months. We hypothesized that individualized TKA demonstrates significantly better functional outcomes than OTS TKA (FJS and percentage of patients reaching the minimum clinically important difference).
View Article and Find Full Text PDFSTAR Protoc
January 2025
Department of Neurosurgery, the First Affiliated Hospital of Jinan University, Guangzhou, China; Department of Neurosurgery, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China; Laboratory of Neurological Diseases and Brain Function, the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China. Electronic address:
Under pathological conditions, astrocytes can transfer mitochondria to neurons, where they exert neuroprotective effects. In this context, we present a protocol for capturing astrocytic mitochondria in neurons of adult mice using a two-photon microscope. We describe an approach for constructing a mouse model with combined labeling of astrocytic mitochondria and neurons.
View Article and Find Full Text PDFCardiovasc Toxicol
January 2025
Department of Cadre Ward, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Harbin, 150001, Heilongjiang, PR China.
Atherosclerosis risk is elevated in diabetic patients, but the underlying mechanism such as the involvement of macrophages remains unclear. Here, we investigated the underlying mechanism related to the pro-inflammatory activation of macrophages in the development of diabetic atherosclerosis. Bioinformatics tools were used to analyze the macrophage-related transcriptome differences in patients with atherosclerosis and diabetic mice.
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