AI Article Synopsis
- The study focuses on isolating, identifying, and synthesizing two natural compounds that inhibit the NF-κB signaling pathway, derived from the iso-tanapartholide family.
- A crucial step in the synthesis involved an oxidative cleavage reaction that effectively produced the natural products without using protective groups.
- Biological tests on the synthesized compounds confirmed their action at a late stage of the NF-κB signaling pathway, providing valuable insights into their function.
Article Abstract
The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-κB signaling pathway from the iso--tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-κB signaling pathway. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627315 | PMC |
| http://dx.doi.org/10.1002/ejoc.200901016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!