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Construction of colorimetric-fluorescent dual-signal aptamer-based assay using COF-Au nanozyme and magnetic nanoparticle-based CdTe quantum dots for sensitive zearalenone determination.
Mikrochim Acta
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State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
A dual-signal aptamer-based assay utilizing colorimetric and fluorescence techniques was developed for the determination of zearalenone (ZEN). The CdTe quantum dots, serving as the fluorescent signal source, were surface-modified onto FeO@SiO and subsequently functionalized with the aptamer. The COF-Au was modified with complementary chain, which possessed peroxide (POD)-like enzyme properties, and could catalyze the peroxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to ox TMB, resulting in the generation of colorimetric signals.
View Article and Find Full Text PDFDepletion-Induced Tunable Assembly of Complementary Platonic Solids.
Nano Lett
December 2024
Laboratoire de Physique des Solides, Université Paris-Saclay, CNRS, Orsay 91405, France.
Multicomponent self-assembly has been explored to create novel metamaterials from nanoparticles of different sizes and compositions, but the assembly of nanoparticles with complementary shapes remains rare. Recent binary assemblies were mediated by DNA base pairing or induced by solvent evaporation. Here, we introduce depletion-induced self-assembly (DISA) as a novel approach to constructing tunable binary lattices.
View Article and Find Full Text PDFAn Intermediate Resolution Model of RNA Dynamics and Phase Separation with Explicit .
bioRxiv
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Department of Chemistry University of Massachusetts, Amherst, MA 01003, USA.
RNAs are major drivers of phase separation in the formation of biomolecular condensates. Recent studies suggest that RNAs can also undergo protein-free phase separation in the presence of divalent ions or crowding agents. Much remains to be understood regarding how the complex interplay of base stacking, base pairing, electrostatics, ion interactions, and structural propensities governs the phase behaviour of RNAs.
View Article and Find Full Text PDFHybrid layer-by-layer assembly of AuNPs/NSF composite for electrochemical detection of miRNA-196a.
Discov Nano
November 2024
Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
Detection of microRNA-196a (miRNA-196a) is crucial in cancer research, enabling early diagnosis and providing guidance for individualized treatment. In this work, we employed a naturally occurring negatively charged nano silk fibroin (NSF) with high mechanical properties, biocompatibility, and conductivity to be encapsulated with a positively charged gold nanoparticles (AuNPs) were used as film-forming materials for electrostatic layer-by-layer self-assembly to modify the working electrode of the screen-printed carbon electrode (SPCE). Under the optimized experimental conditions, the uniformly distributed AuNPs on the surface of the multilayer film modified SPCE (AuNPs/NSF)/SPCE combined with the sulfhydryl-modified capture probe cp-DNA through gold-sulfur bonds.
View Article and Find Full Text PDFComparative analysis of predicted DNA secondary structures infers complex human centromere topology.
Am J Hum Genet
December 2024
Laboratory of Genome Evolution, Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy. Electronic address:
Article Synopsis
- - The text discusses how secondary structures, which are unique arrangements of nucleic acids caused by internal interactions, can occur in both RNA and single-stranded DNA, impacting key processes like DNA replication and transcription, thus affecting genome stability.
- - The study focuses on the comparison of secondary structures in linear single-stranded DNA from different specialized human loci, such as centromeres and coding regions, revealing that centromeres have the highest complexity and instability in their secondary structures.
- - Findings indicate that the intricate self-hybridizing properties of centromeric repeats may lead to chromosome missegregation when chromatin is disrupted, highlighting the functional importance of these structures in various DNA processes like transcription and recombination.
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