AI Article Synopsis
- Aging leads to significant changes in immune response, especially within T cells.
- Cytokines, which are key to immune cell communication, may undergo age-related changes that affect immune function.
- Research shows a potential shift from Th1 to Th2 cytokine responses in mice, but this is less clear in humans, and changes in cytokine production with age are inconsistent across studies.
Article Abstract
Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFNγ) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 studies in humans suggests that age-associated changes in cytokine production are not consistent.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455461 | PMC |
| http://dx.doi.org/10.1007/s11357-998-0024-6 | DOI Listing |
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