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Clinical Significance of MRI-Based Measurements of Tibial Plateau Widening Width and Joint Fluid Volume During Anterior Cruciate Ligament Injuries Among Patients With Tibial Plateau Fractures.
Ann Ital Chir
March 2025
Department of Pediatrics, Mianzhu People's Hospital, 618200 Mianzhu, Sichuan, China.
Aim: This study aimed to explore the diagnostic value of magnetic resonance imaging (MRI)-based tibial plateau widening width (TPW) and joint effusion volume during anterior cruciate ligament (ACL) injuries among patients with tibial plateau fractures.
Methods: This retrospective study collected clinical data from 100 patients with tibial plateau fractures admitted between February 2022 and February 2024. The findings from arthroscopy or surgical intervention served used as the "gold standard".
The Choice of Hip Arthroplasty: HRA or THA? Revealed by Meta-Analysis.
Orthop Surg
March 2025
Department of Orthopaedics, Qingdao Municipal Hospital, Qingdao, China.
Background: Total hip arthroplasty (THA) is the gold standard for end-stage hip arthrosis, while hip resurfacing arthroplasty (HRA) is considered a more bone-conserving alternative. This meta-analysis aimed to compare the safety and clinical efficacy of HRA and THA.
Methods: The databases of PubMed, EMBASE, Cochrane Library, and CNKI were searched for RCTs comparing HRA and THA in treating hip arthrosis from database initiation to April 2024.
Therapeutic drug monitoring of levetiracetam - Is dried blood spot sampling suitable?
Clin Biochem
March 2025
Department of Clinical Pharmacology, Therapeutic Drug Monitoring Laboratory, C2-69, Karolinska University Hospital, Stockholm 141 86, Sweden; Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden.
Background: Therapeutic drug monitoring helps prevent seizures and minimize side effects in epilepsy patients. Phlebotomy is the gold standard for blood collection but can be difficult for children, pregnant women, and patients in remote areas. We previously validated dried blood spot (DBS) sampling for carbamazepine, lamotrigine, levetiracetam (LEV), and valproic acid.
View Article and Find Full Text PDFDiscovery of potential Leonurine-based therapeutic lead MJ210 attenuates Parkinson's disease pathogenesis via NF-κB and MAPK pathways: Mechanistic insights from in vitro and in vivo rotenone models.
Eur J Med Chem
March 2025
Department of Bioscience & Bioengineering, Indian Institute of Technology, Jodhpur, Rajasthan, 342037, India. Electronic address:
Parkinson's disease (PD) is a common neurodegenerative disease affecting motor and non-motor functions, with no effective treatment yet discovered. Neuroprotective compounds, both natural and synthetic, show promise but face challenges such as crossing the blood-brain barrier, limited serum stability, and higher toxicity. To tackle these obstacles, we have devised an innovative design strategy inspired by the neuroprotective properties of Leonurine, widely utilized in managing neurological disorders.
View Article and Find Full Text PDFInnovative antigens for more accurate diagnosis of Q fever.
J Microbiol Methods
March 2025
Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia; National Reference Centre for Surveillance and Laboratory Diagnosis of Rickettsioses, Regional Public Health Authority of the Slovak Republic, Cesta k nemocnici 1, 975 56 Banská Bystrica, Slovakia.
Coxiella burnetii, the causative agent of Q fever, poses a significant public health concern worldwide. Diagnosis primarily relies on serological tests. Traditional antigen production methods, typically involving embryonated hen eggs, are labor-intensive, costly, and require biosafety level 3 facilities.
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