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Multifaceted pulmonary manifestations of amyloidosis: state-of-the-art update.
Expert Rev Respir Med
January 2025
Division of Pulmonary & Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Introduction: Amyloidosis, a polymeric deposition disease classified according to protein subtype, may have varied pulmonary manifestations. Its anatomic-radiologic phenotypes include nodular, cystic, alveolar-septal, and tracheobronchial forms. Clinical presentation may range from asymptomatic parenchymal nodules to respiratory failure from diffuse parenchymal infiltration or diaphragmatic deposition.
View Article and Find Full Text PDFObjectives: To describe the clinical presentation and clinicopathological findings of dogs with nodular splenic lesions composed of heterogeneous cell components associated with systemic inflammation and to provide information on the outcome after surgical resection.
Materials And Methods: Medical records were searched for dogs with histologically and immunohistochemically characterised nodular splenic lesions with mixed stromal, histiocytic and lymphoid cells and the presence of systemic inflammatory markers at the time of diagnosis.
Results: Four dogs were included, of which three had an undifferentiated splenic stromal sarcoma and one had a splenic leiomyosarcoma.
Waxy pink facial lesion on an elderly man.
JAAD Case Rep
January 2025
Banki Dermatology and Cosmetic Center, Glastonbury, Connecticut.
Clinicopathologic, Proteomic and Outcome Characteristics of Renal Apolipoprotein C-II Amyloidosis: A Case Series.
Am J Kidney Dis
November 2024
Department of Laboratory Medicine and Pathology, Rochester, Minnesota. Electronic address:
Article Synopsis
- Amyloidosis derived from apolipoprotein C-II (AApoCII) is a rare condition that primarily affects the kidneys, presenting with symptoms like proteinuria and reduced kidney function, particularly in older patients.
- A study conducted with 25 cases from the Mayo Clinic revealed common histological characteristics, such as nodular amyloid deposits in glomeruli, and proteomic analysis identified specific Apo C-II variants in many patients.
- Despite significant kidney issues, including end-stage kidney disease in about half of the patients, the overall survival rate was more favorable, indicating potential for better outcomes in this condition.
Amyloid Goiter: A Peruvian Case Series.
touchREV Endocrinol
October 2024
CaTaLiNA: Cancer de tiroides en Latinoamerica, Quito, Ecuador.
: Amyloid goiter (AG) is a rare cause of thyroid swelling, characterized by deposits of amyloid protein in the thyroid tissue. It can be associated with primary or secondary amyloidosis. Its prevalence in multinodular goiter cases is 0.
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