Background: Vascular endothelial growth factor-B (VEGF-B) protects against experimental stroke, but the effect of stroke on VEGF-B expression is uncertain.
Methods: We examined VEGF-B expression by immunohistochemistry in the ischemic border zone 1-7 days after middle cerebral artery occlusion in rats.
Results: VEGF-B immunoreactivity in the border zone was increased after middle cerebral artery occlusion and was associated with neurons and macrophages/microglia, but not astrocytes or endothelial cells.
Conclusions: These findings provide additional evidence for a role of VEGF-B in the endogenous response to cerebral ischemia.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671984 | PMC |
| http://dx.doi.org/10.1186/2045-824X-5-8 | DOI Listing |
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