AI Article Synopsis
- The study aimed to explore the expression levels of the long non-coding RNA HOTAIR in ovarian cancer tissues compared to normal ovarian tissues.
- The researchers used real-time fluorescence quantitative PCR to measure HOTAIR mRNA in 44 ovarian cancer samples and 14 normal ovary samples.
- Results showed significantly higher HOTAIR expression in ovarian cancer tissue, especially in poorly differentiated cases, suggesting that HOTAIR could serve as a potential biomarker and therapeutic target for ovarian cancer.
Article Abstract
Objective: To investigate the long non-coding RNA HOTAIR (long non-coding HOX antisense intergenic RNA) by examining HOTAIR expression levels in ovarian cancer tissue and normal ovarian tissue.
Methods: The mRNA of long non-coding RNA HOTAIR expressions were detected by real-time fluorescence quantitative PCR in ovarian cancer (44) and normal ovary tissues (14).
Results: The expression of HOTAIR in ovarian cancer tissue was higher than that in normal ovarian tissue (1.26 +/- 0.27 vs. 0.14 +/- 0.09, P < 0.05). The expression was statistically higher in poorly differentiated ovarian cancer than poorly-moderately, moderately-well, and well-differentiated ones (1.65 +/- 0.41 vs. 0.39 +/- 0.14, P < 0.05).
Conclusion: RNA HOTAIR expressions were higher in ovarian cancer; it may play a role in ovarian cancer, and become a biomarker for malignant degree of ovarian cancer and may provide a novel therapeutic target for ovarian cancer.
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