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Analysis of changes in PCSK9 and TNF-α concentrations in response to physical exercises using virtual reality in patients in the fifth stage of chronic kidney disease undergoing hemodialysis.
BMC Nephrol
January 2025
Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin, 71-210, Poland.
Article Synopsis
- The study investigates the effectiveness of virtual reality (VR) integrated exercise during hemodialysis for patients with stage 5 Chronic Kidney Disease (CKD).
- The research utilized the NefroVR system, allowing patients to perform regular physical training with VR technology.
- Results showed a significant reduction in harmful proteins PCSK9 and TNF-α after three months, indicating potential health benefits from this innovative exercise method.
[Recommendations for the rehabilitation of patients with chronic kidney disease requiring hemodialysis (literature review)].
Vopr Kurortol Fizioter Lech Fiz Kult
December 2024
Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological agency of Russia, Moscow, Russia.
Unlabelled: Chronic kidney disease (CKD) is a global health problem, CKD is widespread in the world, on average it is detected in 10-13% of the adult population. Sedentary patients with CKD on dialysis have a higher risk of mortality. Despite the significant association of physical function with mortality in patients with CKD, physical function is not routinely assessed and exercise is not a component of the routine management of patients with CKD on dialysis.
View Article and Find Full Text PDFThe Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial.
Antioxidants (Basel)
October 2024
Research Laboratory Molecular Bases of Human Pathology LR19ES13, Faculty of Medicine, University of Sfax, Sfax 3029, Tunisia.
Background: This study aimed to investigate the effects of intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation on oxidative stress, inflammation, and cellular damage in hemodialysis (HD) patients.
Methods: Thirty-two HD patients were randomly assigned to three groups: Exercise (EX)-MEL, EX-Placebo (PLA), and Control (C)-PLA. Participants in the EX-MEL and EX-PLA groups underwent 12 weeks of concurrent training.
Effects of intradialytic bicycle ergometer exercise on transcription factors NF-ĸB and Nrf2 in patients with chronic kidney disease: A randomized crossover clinical trial.
J Bodyw Mov Ther
October 2024
Graduate Program in Biological Sciences - Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil; Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil.
Purpose: To evaluate the effects of an intradialytic aerobic exercise training program on the expression of transcription factors nuclear factor κappa B (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2), related to inflammatory and antioxidant pathways, respectively, in patients with chronic kidney disease (CKD) on hemodialysis.
Methods: This was a longitudinal, randomized clinical trial with a washout period and crossover performed with 33 patients randomized into two groups: Exercise (individualized intradialytic aerobic exercise on an adapted stationary exercise bike) three times per week for three months and control (without exercise). After the washout period (1 month), the exercise group became the control, and the other group performed the exercises for another three months.
Efficacy of Aerobic and Stretching Exercises in Managing Willis-Ekbom Disease (Restless Leg Syndrome) Among Hemodialysis Patients.
Cureus
October 2024
Surgery, King Edward Medical University, Lahore, PAK.
Article Synopsis
- - Restless leg syndrome (RLS) is a neurological disorder that leads to a strong urge to move the legs, impacting the quality of life for many hemodialysis patients; this review focuses on exploring exercise as a treatment option.
- - An analysis of eight studies found that aerobic and stretching exercises significantly reduced RLS severity and improved related issues like sleep quality and depression among hemodialysis patients over durations of eight weeks to six months.
- - The findings suggest that exercise can be an effective non-pharmacological approach to managing RLS, potentially serving as an alternative or complement to dopamine agonists (DAs), which have side effects despite improving sleep quality.
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