Synthesis of 1,4,5-trisubstituted 1,2,3-triazoles amicable for automation.

Comb Chem High Throughput Screen

Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, A.P., India.

Published: September 2013

A three-component 3+2 cycloaddition reaction followed by Suzuki coupling reaction was carried out to synthesize a library of compounds using automation (parallel synthesizer). Scaffolds that are unexplored in literature were used for the synthesis of library. The iodo-triazoles formed by 3+2 cycloaddition reaction were coupled with boronic acids to get tri-substituted triazoles.

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http://dx.doi.org/10.2174/1386207311316080009DOI Listing

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