[SNP of rs17321515 homologous with Trib1 in Han population and its correlation with blood lipid].

Objective: To study on genotype distribution of rs17321515 which is homologous with Trib1 and its associativity with blood lipid parameters and diagnosis.

Method: Collecting 1 014 blood samples to measure its lipid levels, then detecting rs17321515 locus's SNP by MALDI-TOF mass spectrometry technology.

Results: Three genotypes (A/A, A/G, G/G) proportions in the population were 13.8%, 50.2% and 36.0%, allele frequencies were A: G = 38.9% : 61.1%. In variance analysis, variation of TG of male was statistical significant (F = 4.46, P = 0.01), TG level of male who carried AG is lower than GG carries ( t = 0.29, P = 0.02). Logistic regression analysis showed that, hypertriglyceridemia prevalence of male who carried AA is lower than GG carries (OR = 0.45, P = 0.04). Low HDL-c acidosis prevalence of male who carried AG is lower than GG carries (OR = 0.62, P = 0.03). Hypercholesterolemia prevalence of female who carried AG is lower than GG carries (OR = 0.58, P = 0.01).

Conclusion: Allele frequencies of rs17321515 varies in different ethnic groups; The locus' polymorphism distribution is relevant with a certain lipid indicators and lipid diagnosis, but there exist gender differences on these relevance.