Chemical constituents from the leaves of Annona reticulata and their inhibitory effects on NO production.

In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC₅₀ values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.