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Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea.
Sci Rep
January 2025
School of Microbiology, University College Cork, Cork, T12 YT20, Ireland.
Floricoccus penangensis ML061-4 was originally isolated from the leaf surface of an Assam tea plant (Camellia sinensis var. assamica) from Northern Thailand. To assess the functions encoded by the F.
View Article and Find Full Text PDFLinkage-based ortholog refinement in bacterial pangenomes with CLARC.
bioRxiv
January 2025
Center for Communicable Disease Dynamics, Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Bacterial genomes exhibit significant variation in gene content and sequence identity. Pangenome analyses explore this diversity by classifying genes into core and accessory clusters of orthologous groups (COGs). However, strict sequence identity cutoffs can misclassify divergent alleles as different genes, inflating accessory gene counts.
View Article and Find Full Text PDFAdvancing Therapeutic and Vaccine Proteins: Switching from Recombinant to Ribosomal Delivery-A Humanitarian Cause.
Int J Mol Sci
November 2024
DEI Biopharma, Kampala P.O. Box 35854, Uganda.
Recombinant therapeutic and vaccine proteins have revolutionized healthcare, but there remain challenges, as many are awaiting development due to their slow development speed and high development cost. Cell-free in vivo ribosomes offer one choice, but they come with similar constraints. The validation of in vivo messenger RNA (mRNA) technology has been accomplished for COVID-19 vaccines.
View Article and Find Full Text PDFDiscovery of : A Novel Fungus Identified Using Genome Sequencing and Metabolomic Analysis.
J Fungi (Basel)
November 2024
National Fungal Culture Collection of India, Biodiversity and Palaeobiology Group, MACS' Agharkar Research Institute, GG Agarkar Road, Pune 411004, India.
In this study, a new species of was isolated as an endophyte from the bark of from Mulshi, Maharashtra. The identity of this isolate was confirmed based on the asexual morphological characteristics as well as multi-gene phylogeny based on the internal transcribed spacer (ITS) and large subunit (LSU) nuclear ribosomal RNA (rRNA) regions. As this was the second species to be reported in this genus, we sequenced the genome of this species to increase our knowledge about the possible applicability of this genus to various industries.
View Article and Find Full Text PDFUnlocking the Mycobacteroides abscessus pan-genome using computational tools: insights into evolutionary dynamics and lifestyle.
Antonie Van Leeuwenhoek
November 2024
Department of Botany, Ramananda College, Life Sciences Block, Bishnupur, West Bengal, 722122, India.
Mycobacteroides abscessus is a non-tuberculous mycobacteria implicated in causing lung infections. It is difficult to control owing to resistance to antibiotics and disinfectants. This work was aimed at comprehending: the pan-genome architecture, evolutionary dynamics, and functionalities of pan-genome components linked to COGs and KEGG.
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