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Control of the STAT6-BCL6 antagonism by SWAP-70 determines IgE production. | LitMetric

Control of the STAT6-BCL6 antagonism by SWAP-70 determines IgE production.

J Immunol

Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, Germany.

Published: May 2013

AI Article Synopsis

  • Asthma and allergies are significantly influenced by Immunoglobulin E (IgE), which drives the release of inflammatory substances from mast cells and basophils, leading to allergic and anaphylactic responses.* -
  • The production of IgE is tightly regulated, as high levels can cause severe immunological issues, with IL-4 playing a crucial role in initiating the switch to IgE production through germline transcription.* -
  • Research shows that SWAP-70 is essential for proper IgE production; its deficiency impairs the interaction of STAT6 with the IgE promoter, resulting in increased BCL6 levels that antagonize STAT6's effects, thereby influencing allergic responses.*

Article Abstract

Asthma and allergies are major health concerns in which Ig isotype E plays a pivotal role. Ag-bound IgE drives mast cells and basophils into exocytosis, thereby promoting allergic and potentially anaphylactic reactions. The importance of tightly regulated IgE production is underscored by severe immunological conditions in humans with elevated IgE levels. Cytokines direct IgH class-switching to a particular isotype by initiation of germline transcription (GLT) from isotype-specific intronic (I) promoters. The switch to IgE depends on IL-4, which stimulates GLT of the Iε promoter, but is specifically and strongly impaired in Swap-70(-/-) mice. Although early events in IL-4 signal transduction (i.e., activation of the JAK/STAT6 pathway) do not require SWAP-70, SWAP-70 deficiency results in impaired Iε GLT. The affinity of STAT6 to chromatin is reduced in absence of SWAP-70. Chromatin immunoprecipitation revealed that SWAP-70 binds to Iε and is required for association of STAT6 with Iε. BCL6, known to antagonize STAT6 particularly at Iε, is increased on Iε in absence of SWAP-70. Other promoters bound by BCL6 and STAT6 were found unaffected. We conclude that SWAP-70 controls IgE production through regulation of the antagonistic STAT6 and BCL6 occupancy of Iε. The identification of this mechanism opens new avenues to inhibit allergic reactions triggered by IgE.

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Source
http://dx.doi.org/10.4049/jimmunol.1203014DOI Listing

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