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Chapter 6: SYNDROMIC PRIMARY HYPERPARATHYROIDISM.

Ann Endocrinol (Paris)

January 2025

Endocrinology Department, Huriez Hospital, Lille University Hospital, France. Electronic address:

Syndromic primary hyperparathyroidism has several features in common: younger age at diagnosis when compared with sporadic primary hyperparathyroidism, often synchronous or metachronous multi-glandular involvement, higher possibility of recurrence, association with other endocrine or extra-endocrine disorders, and suggestive family background with autosomal dominant inheritance. Hyperparathyroidism in multiple endocrine neoplasia type 1 is the most common syndromic hyperparathyroidism. It is often asymptomatic in adolescents and young adults, but may be responsible for recurrent lithiasis and/or bone loss.

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Background: Multiple and complicated hepatolithiasis can be associated with decompensated cirrhosis. Endoscopic retrograde cholangiopancreatography is unavailable for multiple and complicated hepatolithiasis, and the mainstay for decompensated cirrhosis is liver transplantation. However, due to the ethical factors and the complexity of operation, liver transplantation cannot be widely operated.

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Choledocholithiasis is the second most common complication of gallstone disease. Giant primary choledocholithiasis is a rare occurrence. Ultrasonography is the initial mode of imaging, and endoscopic ultrasound is considered superior to other modalities.

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Hematuria is a frequent entity in primary care. The differential diagnosis covers multiple causes: physiological, pharmacological, false hematuria and urological pathologies, being fundamental in its study to assess the possible malignant neoplastic causes. Urologic ultrasound is a non-invasive technique, using a 3.

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Article Synopsis
  • The study compares the effectiveness and safety of three treatments for acute upper urinary tract obstruction due to kidney stones: mini percutaneous nephrostomy (MPCN), micropercutaneous nephrostomy (MicroPCN), and retrograde ureteric stenting (RUS).
  • A total of 64 patients were analyzed based on specific criteria, with findings showing no significant differences in infection indicators or complications among the groups.
  • MicroPCN was highlighted as particularly beneficial for severely ill patients or those with complicated cases, despite showing the lowest overall patient condition and requiring longer hospital stays compared to the other treatments.
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