Objectives: To apply the diagnostic criteria of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the criteria of the European Society for Study of Interstitial Cystitis (ESSIC) in our population with Bladder Pain Syndrome /interstitial cystitis (BPS/IC).
Methods: A cohort of 36 patients with the endoscopic clinical diagnosis of BPS/IC were evaluated retrospectively in the Hospital de Clinicas José de San Martin and Urology Center CDU over a period of 5 year. Cystoscopy with diagnostic and therapeutic hydrodistention was applied a to all patients. The NIDDK criteria were applied to the patients with endoscopic clinical diagnosis of BPS/IC. The new criteria proposed by the ESSIC were contrasted and results were compared.
Results: Of a total of 36 patients treated, 33 were women and 3 were men with ages between 30 and 75 years, 100% presented pain or urgency. Glomerulation or Hunner lesions appeared in 30 patients (83%). 35 patients (97%) had urinary frequency >8/day, and 22 patients (61%) had bladder capacity <350 cc. Only 22 patients (61%) completed the strict diagnostic criteria of the NIDDK. On the other hand, using the new criteria proposed by the ESSIC for the diagnosis of BPS/IC 35 patients (97%) were included in this pathology, with normal cystoscopy in 6 patients (17%) and 14 patients (39%) with bladder capacity >350 cc.
Conclusion: The widest diagnostic criteria of the ESSIC allow the inclusion of more patients in the certainty diagnosis of BPS/IC than the NIDDK criteria, facilitating the diagnosis of this strange urological disease.
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Both the clinical management and study of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) is complicated by significant heterogeneity in the etiology, mechanisms, symptoms, and complications of pancreatitis. The National Institutes of Diabetes and Digestive and Kidney Disease (NIDDK) recently convened a workshop to address current knowledge and knowledge gaps in the field. Preclinical models that better replicate human disease are important for development of new therapies.
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