A heterobimetallic CuNi bis(μ-oxo) diamond core is shown to possess nucleophilic oxo groups, and has been demonstrated for the first time as a viable intermediate during the deformylation of fatty aldehydes by cyanobacterial aldehyde decarbonylase.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084805PMC
http://dx.doi.org/10.1002/anie.201300861DOI Listing

Publication Analysis

Top Keywords

nucleophilic oxo
8
oxo groups
8
high-valent heterobimetallic
4
heterobimetallic [cuiiiμ-o2niiii]2+
4
[cuiiiμ-o2niiii]2+ core
4
core nucleophilic
4
groups heterobimetallic
4
heterobimetallic cuni
4
cuni bisμ-oxo
4
bisμ-oxo diamond
4

Similar Publications

Diastereoselective synthesis of -3,4-difunctionalized tetrahydroquinoline and chromane derivatives via the oxo-sulfonylation of 1,7-enynes is demonstrated. The reaction involves a three-component oxidative radical polar crossover (ORPC) approach wherein a vinyl carbocation intermediate undergoes nucleophilic substitution to afford the corresponding keto functional group. Deprotection of the N-Ts group, gram-scale synthesis, and other synthetic applications were illustrated.

View Article and Find Full Text PDF

Herein we describe the synthesis and rearrangement of 1,3-diamino-2,7-naphthyridines and 1-amino-3-oxo-2,7-naphthyridines. In the case of 1,3-diamino-2,7-naphthyridines, it was found that the rearrangement reaction was influenced by both the substituent at the 7th position of the 2,7-naphthyridine ring and by the nature of the cyclic amine at the 1st position. The influence was mainly steric.

View Article and Find Full Text PDF

Lipoxin A yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling.

J Lipid Res

November 2024

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

The enzymatic oxidation of arachidonic acid is proposed to yield trihydroxytetraene species (termed lipoxins) that resolve inflammation via ligand activation of the formyl peptide receptor, FPR2. While cell and murine models activate signaling responses to synthetic lipoxins, primarily lipoxin A (LXA), there are expanding concerns about the reported biological formation, detection, and signaling mechanisms ascribed to LXA and related di- and tri-hydroxy ω-6 and ω-3 fatty acids. The generation and signaling actions of LXA and its primary 15-oxo metabolite were assessed in control, lipopolysaccharide-activated, and arachidonic acid-supplemented RAW264.

View Article and Find Full Text PDF

Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas.

Science

November 2024

Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

Unsymmetrical ureas are commonly found in pharmaceuticals and bioactive compounds. However, devising strategies to introduce two distinct amines selectively in the construction of unsymmetrical ureas remains a challenge. In this work, we use a synchronous recognition strategy that takes advantage of radical and nucleophilic activation to discriminate between secondary and primary amines.

View Article and Find Full Text PDF

Mechanistic insights into multimetal synergistic and electronic effects in a hexanuclear iron catalyst with a [Fe(μ-O)(μ-OH)] core for enhanced water oxidation.

Dalton Trans

November 2024

National Laboratory of Solid State Microstructures and Jiangsu Provincial Key Laboratory for Nanotechnology, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China.

Article Synopsis
  • Researchers developed a bio-inspired hexanuclear iron(III) complex designed for efficient water oxidation, offering water solubility and stability.
  • This complex operates via the water nucleophilic attack pathway with a low overpotential of 290 mV in acidic conditions.
  • The study highlights the roles of high-oxidation-state intermediates and reversible proton transfer in enhancing the catalyst's performance, paving the way for better molecular catalysts in future designs.*
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!