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Exercise-induced bronchoconstriction in children: Delphi study and consensus document about definition and epidemiology, diagnostic work-up, treatment, and follow-up.
Respir Res
December 2024
Department of Medicine and Surgery, Pediatric Clinic, University of Parma, Via Gramsci 14, 43126, Parma, Italy.
Background: Exercise-induced bronchoconstriction (EIB) is common in children with asthma but can be present also in children without asthma, especially athletes. Differential diagnosis includes several conditions such as exercise-induced laryngeal obstruction (EILO), cardiac disease, or physical deconditioning. Detailed medical history, clinical examination and specific tests are mandatory to exclude alternative diagnoses.
View Article and Find Full Text PDFChanges in sex composition of births across regions and subgroups in India from an analysis of birth histories from National Family Health Surveys.
Sci Rep
December 2024
Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA.
India has consistently had one of the highest birth sex ratios (i.e., most males per female) globally.
View Article and Find Full Text PDF26 Years of Skin Banking in Finland.
Eur Burn J
December 2024
Helsinki Burn Centre, Department of Plastic Surgery, Helsinki University Hospital and University of Helsinki, 00029 Helsinki, Finland.
Autologous skin grafts are the gold standard for definitive wound coverage in burn care, but allograft skin grafts are essential for providing temporary coverage in cases of extensive burns. The Helsinki Skin Bank, established in 1995 at the Helsinki Burn Centre, is Finland's only licensed skin bank, serving a population of 5.5 million.
View Article and Find Full Text PDFA Pharmacokinetic/Toxicodynamic Model of Cisplatin Nephrotoxicity Using the Kidney Injury Molecule-1 Biomarker.
J Pharmacol Clin Toxicol
September 2024
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, USA.
Cisplatin is a platinum-based chemotherapeutic that causes acute kidney injury in over 30% of patients. The aim of this study was to develop a population pharmacokinetic/toxicodynamic (PKTD) model of cisplatin-induced kidney injury that incorporated plasma total platinum and urinary kidney injury molecule-1 (KIM-1) concentrations. Cancer patients receiving their first or second round of cisplatin-containing chemotherapy (n=39) were prospectively randomized to a 5-HT antagonist (5-HTA) antiemetic (ondansetron, granisetron, or palonosetron) and had blood and urine collected over 10 days.
View Article and Find Full Text PDFInjury Risk Factors Related to Sport Specialization in High School Basketball: A Prospective Study.
J Athl Train
December 2024
Division of Athletic Training, School of Applied Health Sciences and Wellness, Ohio University, Athens.
Context: Research that has examined the association between specialization and injury in basketball has been limited to cross-sectional or retrospective studies.
Objective: To determine whether specialization is a risk factor for injury among high school basketball athletes.
Design: Prospective cohort study.
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